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Now showing items 1 - 4 of 4

  • Patient blood management. Current state of the literature

    Meybohm, P.   Fischer, D.   Schnitzbauer, A.   Zierer, A.   Schmitz-Rixen, T.   Bartsch, G.   Geisen, C.   Zacharowski, K.  

    Preoperative anemia has a prevalence of approximately 30 % and is one of the strongest predictors of perioperative red blood cell (RBC) transfusion. It is rarely treated although it is an independent risk factor for the occurrence of postoperative complications. Additionally, the high variability in the worldwide usage of RBC transfusions is alarming. Due to these serious deficits in patient care, in 2011 the World Health Organization recommended the implementation of a patient blood management (PBM). This article provides information about PBM as a multidimensional and interdisciplinary approach. A selective literature search was carried out in the Medline and Cochrane library databases including consideration of national and international guidelines. A PBM promotes the medically and ethically appropriate use of all available resources, techniques and materials in favor of an optimized perioperative patient care. Patients' own resources should be specifically protected, strengthened and used and include (i) diagnosis and therapy of preoperative anemia, (ii) minimizing perioperative blood loss, (iii) blood-conserving surgical techniques, (iv) restriction of diagnostic blood sampling, (v) utilization of individual anemia tolerance, (vi) optimal coagulation and hemotherapy concepts and (vii) guideline-based, rational indications for the use of RBC transfusions. A PBM should be advocated as an incentive to evaluate and critically optimize local conditions. An individual, interdisciplinarily structured bundle of different PBM measures has great potential to optimize the quality of patient care and to make it safer.
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  • Giant Cell Hepatitis: an Unusual Cause of Fulminant Liver Failure

    Hartl, J.   Buettner, R.   Rockmann, F.   Farkas, S.   Holstege, A.   Vogel, C.   Schnitzbauer, A.   Schlitt, H. J.   Schoelmerich, J.  

    Giant cell hepatitis is a very rare disease of unknown origin. It has been hypothesized that drugs, viral infections, or autoimmune reactions may play a pathogenetic role. Here, we describe a 33 year old patient with bacterial bronchitis who was treated with doxycycline (100 mg/d) for one week. Furthermore the patient complained of malaise and a distinct jaundice. Liver parameters increased dramatically (AST 4670 U/l, ALT 5350U/l, bilirubin 226 mu mol/l) and liver function was impaired (INR=1,45). The ultrasound scan showed a hepatomegaly with no signs of cirrhosis, normal spleen size and normal bile ducts; liver perfusion was normal. No evidence of Wilson's disease, hemochromatosis, autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cirrhosis, hepatitis A, B, C and E, HIV, CMV, VZV, adenoviral infections, or paracetamol intoxication was found. Subsequently, the patient developed acute liver failure (AST 2134 U/l, ALT 2820 U/l, bilirubin 380 mu mol/l, INR 3.0) and a beginning renal failure. Therefore, he was transferred to our transplant center. Due to increasing confusion and somnolence due to cerebral edema mechanical ventilation was needed. Because of an acute renal failure and severe hepatic encephalopathia MARS-hemodialysis was performed. Three weeks after the appearance of the jaundice he underwent liver transplantation (MELD 40). Surprisingly, in the explanted liver the diagnosis of giant cell hepatitis was made. Today - 2 years after successful liver transplantation - the patient is in a very good condition with normal liver function. In conclusion, giant cell hepatitis is a rare cause of acute liver failure that is often recognized only histologically.
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  • Sirolimus use in liver transplant recipients with hepatocellular carcinoma: A randomized, multi-centre, open-label phase 3 trial – The SiLVER-study

    Schnitzbauer, A.   Schlitt, H.J.   Geissler, E.K.  

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  • EORTC 1409 GITCG / ESSO 01 - A prospective colorectal liver metastasis database with an integrated quality assurance program (CLIMB): Primary analysis of variations in European clinical practices and surgical complications after complex liver metastasis surgeries

    Caballero, C.I.   Alvarez, L. Carrion   Nilsson, H.   Ruers, T.   Senellart, P.   Rivoire, M.   Staettner, S.   Primavesi, F.   Troisi, R.   Gruenberger, T.   Heil, J.   Schnitzbauer, A.   Rahbari, N.   Swijnenburg, R.J.   Malik, H.   Protic, M.   Neven, A.   Mauer, M.   Poston, G.   Evrard, S.  

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