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Now showing items 113 - 128 of 62132

  • D. S. Carne-Ross, 1921-2010

    John Talbot  

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  • Aberrant progranulin,YKL-40,cathepsin D and cathepsin S in Gaucher disease

    Afinogenova, Yuliya   Ruan, Jiapeng   Yang, Ruhua   Kleytman, Nathaniel   Pastores, Gregory   Lischuk, Andrew  

    In Gaucher disease, several macrophage-specific biomarkers have been validated for use in the clinic. However, Gaucher disease is more complex involving system-wide pathophysiology beyond the macrophage, and based on gene array analysis in our Gaucher disease mouse model and other emerging pathophysiologic insights, we evaluated serum levels of cathepsins D and S, YKL-40 and progranulin in Gaucher disease patients. We assessed their biomarker potential in Gaucher disease and compared them to established Gaucher disease biomarkers, chitotriosidase, chemokine ligand 18 (CCL18), and other indicators of disease severity and response to therapy. Mean YKL-40 and cathepsin D and S levels were significantly higher in Gaucher disease patients compared to healthy controls; in contrast, mean progranulin levels were lower in Gaucher disease patients compared to healthy controls. Enzyme replacement therapy resulted in a significant reversal of elevated cathepsin D and S but there was no change in progranulin and YKL-40 levels. Patients with persistent splenomegaly after long-term enzyme replacement therapy had significantly higher serum YKL-40 than patients with smaller spleens (63.0 +/- 6.4 ng/ml vs. 46.4 +/- 4.3 ng/ml, p =3D .03). Serum YKL-40 levels were higher in subjects with severe bone involvement (Hermann Score 3 to 5) compared to those with milder bone involvement (Hermann Score 1 to 2) (70.1 +/- 4.3 ng/ml vs. 48.1 +/- 3.7 ng/ml, p =3D .0002). YKL-40 was only weakly associated with chitotriosidase (r =3D 0.2, p =3D .008) and CCL18 (r =3D 0.3, p =3D .0004), and cathepsin S was moderately associated with chitotriosidase (r =3D 0.4, p =3D .01) and CCL18 (r =3D 0.6, p < .0001). Receiver operating curves for progranulin and YKL-40 demonstrated areas under the curves of 0.80 and 0.70, respectively. In conclusion, while these biomarkers do not meet robust properties of established macrophage-specific biomarkers, they may inform severity of skeletal disease, contribution of fibrosis to residual splenomegaly, and other disease manifestations. These findings, including markedly low progranulin levels that do not change upon enzyme replacement therapy, are intriguing to prompt further investigations to decipher their role in pathophysiology and relevance to diverse phenotypes of Gaucher disease.
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  • Kriterien der elektiven Konkurrenz i. S. d. § 213 Alt. 1 BGB

    Peters, Frank  

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  • Schiff\"s Diseases of the Liver || Hepatitis B and D

    Schiff, Eugene R.   Maddrey, Willis C.   Reddy, K. Rajender  

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  • Analysis of the\\(B_{s}\\rightarrow \\bar{D}^{0} \\phi\\)decay

    Rahim Talebtash, Mohammad   Asadi, Amin   Mehraban, Hossein  

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  • Vermögensnachteil i. S. d. § 266 StGB bei Zahlung auf Nichtige Forderung

    Nestler, N.  

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  • 4H-SiC nMOSFETs with As-Doped S/D and NbNi Silicide Ohmic Contacts

    Nagatsuma, Hirofumi; Kuroki, Shin Ichiro; de Silva, Milantha; Ishikawa, Seiji; Maeda, Tomonori; Sezaki, Hiroshi; Kikkawa, Takamaro; Östling, Mikael; Zetterling, Carl Mikael  

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  • Kriterien der elektiven Konkurrenz i. S. d. § 213 Alt. 1 BGB

    Peters   Frank  

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  • Anticipatory Behavior in Response to Medicare Part D\"s Coverage Gap

    Kaplan, Cameron M.   Zhang, Yuting  

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  • 4H-SiC nMOSFETs with As-Doped S/D and NbNi Silicide Ohmic Contacts

    Nagatsuma, Hirofumi   Kuroki, Shin Ichiro   de Silva, Milantha   Ishikawa, Seiji   Maeda, Tomonori   Sezaki, Hiroshi   Kikkawa, Takamaro   ?stling, Mikael   Zetterling, Carl Mikael  

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  • The superconformal index of class S theories of type D

    Lemos, Madalena   Peelaers, Wolfger   Rastelli, Leonardo  

    We consider the superconformal index of class S theories of type D, which arise by compactification of the (2, 0) D-n theories on a punctured Riemann surface C. We also allow for the presence of twist lines on C associated to the Z(2) outer automorphism of D-n. For the two-parameter slice (p = 0, q, t) in the space of superconformal fugacities, we determine the 2d TQFT that computes the index.
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  • A 400-MS/s 12-bit current-steering D/A converter

    Wang, Shaopeng; Ren, Yannan; Li, Fule; Wang, Zhihua  

    This paper presents a 400-MS/s 12-bit CMOS current-steering digital-to-analog converter (DAC). The proposed DAC adapts 6+2+4 segmented architecture and a modified switching scheme to improve dynamic and static performance. The measured spurious-free dynamic range is up to 77.18 dB at 400 MS/s with a 10 MHz input signal. The full-scale output current is 20 mA with a 1.8 V single power supply. The core area occupies 0.6 mm 2 in a standard 1P-6M 0.18- mu m CMOS process.
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  • 54 - Pre-Diagnosis Vitamin D Levels and the Risk of Crohn\"s Disease

    Limketkai, Berkeley   Singla, Manish   Rodriguez, Benjamin   Veerappan, Ganesh   Betteridge, John   Hutfless, Susan M.   Brant, Steven R.  

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  • VITAMINE D EN CARI?S

    Bohn Stafleu van Loghum  

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  • A 400-MS/s 12-bit current-steering D/A converter

    Wang, Shaopeng   Ren, Yannan   Li, Fule   Wang, Zhihua  

    This paper presents a 400-MS/s 12-bit CMOS current-steering digital-to-analog converter (DAC). The proposed DAC adapts 6+2+4 segmented architecture and a modified switching scheme to improve dynamic and static performance. The measured spurious-free dynamic range is up to 77.18 dB at 400 MS/s with a 10 MHz input signal. The full-scale output current is 20 mA with a 1.8 V single power supply. The core area occupies 0.6 mm 2 in a standard 1P-6M 0.18- mu m CMOS process.
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  • Effective indirect multi-site spin–spin interactions in the s–d(f) model

    K.K. Komarov   D.M. Dzebisashvili  

    Abstract Using the diagram technique for Matsubara Green's functions it is shown that the dynamics of the localized spin subsystem in the s–d(f) model can be described in terms of an effective spin model with multi-site spin–spin interactions. An exact representation of the action for the effective purely spin model is derived as an infinite series in powers of s–d(f) exchange interaction J . The indirect interactions of the 2nd, 3rd and 4th order are discussed. Highlights • Localized spins in the s-d-model are described within effective purely spin model with multi-site spin-spin interactions. • The action for corresponding purely spin model is derived as an infinite series in powers of s-d(f) exchange interaction. • The indirect interactions of the 2nd, 3rd and 4th order are discussed.
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