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Now showing items 1 - 16 of 2818

  • Spezielle p?diatrische Notf?lle in der Pr?hospitalphase

    Meyer, S.   Grundmann, U.   Reinert, J.   Gortner, L.  

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  • Genetic determinants of P wave duration and PR segment.

    Verweij, Niek   Mateo Leach, Irene   van den Boogaard, Malou   van Veldhuisen, Dirk J   Christoffels, Vincent M   Hillege, Hans L   van Gilst, Wiek H   Barnett, Phil   de Boer, Rudolf A   van der Harst, Pim  

    BACKGROUND: The PR interval on the ECG reflects atrial depolarization and atrioventricular nodal delay which can be partially differentiated by P wave duration and PR segment, respectively. Genome-wide association studies have identified several genetic loci for PR interval, but it remains to be determined whether this is driven by P wave duration, PR segment, or both.; METHODS AND RESULTS: We replicated 7 of the 9 known PR interval loci in 16 468 individuals of European ancestry. Four loci were unambiguously associated with PR segment, while the others were shared for P wave duration and PR segment. Next, we performed a genome-wide analysis on P wave duration and PR segment separately and identified 5 novel loci. Single-nucleotide polymorphisms in KCND3 (P=3D8.3*10(-11)) and FADS2 (P=3D2.7*10(-8)) were associated with P wave duration, whereas single-nucleotide polymorphisms near IL17D (P=3D2.3*10(-8)), in EFHA1 (P=3D3.3*10(-10)), and in LRCH1 (P=3D2.1*10(-8)) were associated with PR segment. Analysis on DNA elements indicated that genome-wide significant single-nucleotide polymorphisms were enriched at genomic regions suggesting active gene transcription in the human right atrium. Quantitative polymerase chain reaction showed that genes were significantly higher expressed in the right atrium and atrioventricular node compared with left ventricle (P=3D5.6*10(-6)).; CONCLUSIONS: Genetic associations of PR interval seem to be mainly driven by genetic determinants of the PR segment. Some of the PR interval associations are strengthened by a directional consistent effect of genetic determinants of P wave duration. Through genome-wide association we also identified genetic variants specifically associated with P wave duration which might be relevant for cardiac biology. =C2=A9 2014 American Heart Association, Inc.
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  • Genetic Determinants of P Wave Duration and PR Segment

    Verweij, N.   Leach, I. M.   van den Boogaard, M.   van Veldhuisen, D. J.   Christoffels, V. M.   Hillege, H. L.   van Gilst, W. H.   Barnett, P.   de Boer, R. A.   van der Harst, P.  

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  • Espacio p=C3=BAblico y pr=C3=A1cticas corporales: un estudio de caso

    Guzm=C3=A1n-Ariza, Claudia Maritza   Chaparro-Hurtado, H=C3=A9ctor Rolando   Gonz=C3=A1lez-Ulloa, Elkin Orlando  

    The article analyzes the effects generated by the relationship between corporal practices and public space in the municipality of Villavicencio, Colombia. In view of its qualitative and comprehensive character, it follows theoretical positions on the corporal practices, the body, the public space and the forms of inclusion and exclusion that emerge from these relations. Likewise, it allows to show new scenarios of participation and linkage in analyzing the derivations of social order intersected by concrete forms of bodily manifestation. This is how the use of physical spaces, the activities performed there and the ways in which the subjects interact, produces a display of social subjectivities and effects that, in the end, redefine the meaning and use of public space. The results of this project will allow us to provide indications to the new forms of reconfiguration of the public space in the city of Villavicencio since the participation of young people.=09
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  • Die phraseologische Konstruktionsfamilie [X Pr?p Hand Verb]

    Staffeldt   Sven  

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  • Pr?implantationsdiagnostik (PID) aus p?diatrischer Sicht

    H.-J. Nentwich   Deutsche Akademie für Kinder- und Jugendmedizin e.V. (DAKJ), Berlin  

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  • Short-term repeatability of electrocardiographic P wave indices and PR interval

    Snyder, Michelle L.   Soliman, Elsayed Z.   Whitsel, Eric A.   Gellert, Kapuaola S.   Heiss, Gerardo  

    Background: P wave indices and PR interval from 12-lead electrocardiograms (ECGs) are predictors of cardiovascular morbidity and mortality, but their repeatability has not been examined. Objectives: Determine the short-term repeatability of P wave indices (P axis, maximum P area and duration, P dispersion and P terminal force in V1) and PR interval. Methods: Participants (n = 63) underwent two standard ECGs at each of two visits, two weeks apart. We calculated the intra-class correlation coefficient (ICC), weighted kappa, and minimal detectable change and difference. Results: ICCs were 0.93 for PR interval, 0.78 for P axis, 0.77 for maximum P area, and 0.58 for maximum P duration. Within- and between-visit Kappa were 0.30 and 0.11 for P dispersion, and 0.68 and 0.46 for P terminal force. Conclusion: Repeatability of PR duration was excellent, that of P wave axis and maximum area was fair, and maximum P wave duration and terminal force was poor. Repeatability of P wave dispersion was fair within visit, yet poor between visits. These results illustrate potential biases when measurement error of some P wave indices is ignored in clinical and epidemiologic studies. (C) 2014 Elsevier Inc. All rights reserved.
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  • P?diatrische Notf?lle in der pr?hospitalen Notfallmedizin

    M. Bernhard   M. Helm   T. Luiz   G. Biehn   M. Kumpch   C. Hainer   J. Meyburg   A. Gries  

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  • Une intervention préventive communautaire en périnatalité

    J. Tissier, A. Bouchouchi, C. Glaude, A. Legge, S. Dé   sir, T. Greacen, R. Dugravier  

    CAPEDP (compétences parentales et attachement dans la petite enfance : diminution des risques liés aux troubles de santé mentale et promotion de la résilience [parenting competencies and attachment in the early childhood: diminution of the health mental problems and promotion of resilience]) is an action research in perinatal prevention targeting young mothers who accept home-visiting support during pregnancy and up until their first child's second birthday. Participation is proposed at the maternity hospital to women presenting specific psychosocial vulnerability factors. The study aims to describe and assess the impact of a manualised mental health promotion programme. Particular attention is paid to promoting secure mother-child attachment and preventing maternal depression, a recognised obstacle to a healthy relationship between mother and baby, so essential for the child's developpement. In other situations, young parents may not have sufficient knowledge or support to develop effective parenting skills in this important and delicate period of the child's life. The article describes the work done with these families in the light of the theoretical foundations underpinning this approach.
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  • Pr=C3=A1ticas de autocuidado em hansen=C3=ADase: face, m=C3=A3os e p=C3=A9s

    Lima, Marize Concei=C3=A7=C3=A3o Ventin   Barbosa, Fernanda Ribeiro   Santos, Danielle Christine Moura dos   Nascimento, Raphaela Delmondes do   D=E2=80=99Azevedo, Stephanie Steremberg Pires  

    ABSTRACT OBJECTIVE To analyze the self-care practices on the face, hands and feet carried out by people affected by Hansen=E2=80=99s disease. METHODOLOGY A qualitative study, carried out in reference units for Hansen=E2=80=99s disease in Pernambuco, between May 2014 and April 2015, with 24 people. Data was collected through the semi-structured interview and content analysis was carried out. RESULTS Two categories emerged: Knowledge and execution of self-care practices in Leprosy and Singularities and challenges for self-care. The study found that respondents are familiar with information about face, hand and foot care, but report difficulties such as low income to acquire material for self-care, lack of time, and some lack of interest. Most of them already presented a degree of incapacity. CONCLUSIONS The training of professionals who work on the empowerment of people facing the disease, guidelines on prevention of disabilities and access to inputs for carrying out self-care are necessary.=09
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  • Imagens de ultrasonografia de l=C3=ADngua pr=C3=A9 e p=C3=B3s terapia de fala

    Melo, Roberta Michelon   Dias, Roberta Freitas   Mota, Helena Bolli   Mezzomo, Carolina Lisb=C3=B4a  

    ABSTRACT The aim of this study was to analyze the ultrasound imaging of the tongue movement during the production of alveolar and velar stops, before and after speech therapy. A boy of a five year old and with Speech Disorder participated in this study. Were collected the articulatory data (ultrasound imaging of the tongue movement) and perceptive hearing of [t], [d], [k] and [g], before and after the 25 speech therapy sessions. Regarding results obtained in pre-therapy moment, when observing the three repetitions of the tongue curve of velar stops, a gestural indifferentiation was apparently detected, suggesting the presence of a dependency between the organizers of tip and body of the tongue. In the after therapy, a change in the tracing of the tongue gesture of [k] and [g] was verified. They started presenting a posteriorization of the tongue movement, synchronously with a rise in its body, as the adult standard. Thus, ultrasonographic findings were able to show a possible overcoming of the anteriorization stop velar, detected in the first perceptual speech analysis. In addition, these results seemed to reinforce the idea of covert contrasts in the speech of children with speech disorders.=09
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  • La pédopsychiatrie : prévention et prise en charge

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  • Variables psicol=C3=B3gicas asociadas a la pr=C3=A1ctica competitiva en p=C3=A1del

    Casals, C.   S=C3=A1nchez-Alcaraz, B.J.   Courel-Ib=C3=A1=C3=B1ez, J.   Mart=C3=ADnez-L=C3=B3pez, J.   Su=C3=A1rez-Cadenas, E.  

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  • Pré-éclampsie et paralysie faciale périphérique idiopathique

    N. Mathieua   J.-F. Ledigabela  

    We describe here the case of a patient affected with pre-eclampsia and who had ididiopathic facial palsy and HELLP syndrome during the puerperium. It developed favourably with a treatment associated with an antihypertensive medicine, corticoid therapy and ophtalmological care. There is an association between pre-eclampsia and idiopathic facial palsy during pregnancy. This can be explained by identical physiopathological mechanisms. Facial palsy generally appears in the course of the third trimester of pregnancy or during the early puerperium. The prognosis is usually good and does not seem to be influenced by pregnancy. When idiopathic facial palsy appears during pregnancy, evidence of pre-eclampsia must be looked for.
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  • Drei Abla?urkunden für das Pr?monstratenserstift P?hlde aus dem 13. Jahrhundert

    K?nighaus   Waldemar  

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  • Conhecimentos e pr=C3=A1ticas para a preven=C3=A7=C3=A3o do p=C3=A9 diab=C3=A9tico

    Ramirez-Perdomo, Claudia   Perdomo-Romero, Alix   Rodr=C3=ADguez-V=C3=A9lez, Mar=C3=ADa  

    Abstract OBJECTIVE Describe the knowledge and practices performed by people for diabetic foot prevention. METHODS This was a cross-sectional, descriptive study, with a random stratified sample, comprised of 304 people with type 2 diabetes mellitus. The information was collected through an instrument designed by the researchers that assessed sociodemographic aspects, and level of knowledge and practices of the participants in diabetic foot care prevention. RESULTS In the assessment of diabetic foot care prevention, there was a low and average level of knowledge, whereas practices were moderately adequate. CONCLUSIONS The results for diabetic foot prevention knowledge and practices are not very encouraging. In light of this situation, primary care programs are important, where nurses provide effective education, as a mechanism for modifying the behavior of people with diabetes mellitus.=09
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