Verweij, Niek
Mateo Leach, Irene
van den Boogaard, Malou
van Veldhuisen, Dirk J
Christoffels, Vincent M
Hillege, Hans L
van Gilst, Wiek H
Barnett, Phil
de Boer, Rudolf A
van der Harst, Pim
BACKGROUND: The PR interval on the ECG reflects atrial depolarization and atrioventricular nodal delay which can be partially differentiated by P wave duration and PR segment, respectively. Genome-wide association studies have identified several genetic loci for PR interval, but it remains to be determined whether this is driven by P wave duration, PR segment, or both.; METHODS AND RESULTS: We replicated 7 of the 9 known PR interval loci in 16 468 individuals of European ancestry. Four loci were unambiguously associated with PR segment, while the others were shared for P wave duration and PR segment. Next, we performed a genome-wide analysis on P wave duration and PR segment separately and identified 5 novel loci. Single-nucleotide polymorphisms in KCND3 (P=3D8.3*10(-11)) and FADS2 (P=3D2.7*10(-8)) were associated with P wave duration, whereas single-nucleotide polymorphisms near IL17D (P=3D2.3*10(-8)), in EFHA1 (P=3D3.3*10(-10)), and in LRCH1 (P=3D2.1*10(-8)) were associated with PR segment. Analysis on DNA elements indicated that genome-wide significant single-nucleotide polymorphisms were enriched at genomic regions suggesting active gene transcription in the human right atrium. Quantitative polymerase chain reaction showed that genes were significantly higher expressed in the right atrium and atrioventricular node compared with left ventricle (P=3D5.6*10(-6)).; CONCLUSIONS: Genetic associations of PR interval seem to be mainly driven by genetic determinants of the PR segment. Some of the PR interval associations are strengthened by a directional consistent effect of genetic determinants of P wave duration. Through genome-wide association we also identified genetic variants specifically associated with P wave duration which might be relevant for cardiac biology. =C2=A9 2014 American Heart Association, Inc.
The article analyzes the effects generated by the relationship between corporal practices and public space in the municipality of Villavicencio, Colombia. In view of its qualitative and comprehensive character, it follows theoretical positions on the corporal practices, the body, the public space and the forms of inclusion and exclusion that emerge from these relations. Likewise, it allows to show new scenarios of participation and linkage in analyzing the derivations of social order intersected by concrete forms of bodily manifestation. This is how the use of physical spaces, the activities performed there and the ways in which the subjects interact, produces a display of social subjectivities and effects that, in the end, redefine the meaning and use of public space. The results of this project will allow us to provide indications to the new forms of reconfiguration of the public space in the city of Villavicencio since the participation of young people.=09
Snyder, Michelle L.
Soliman, Elsayed Z.
Whitsel, Eric A.
Gellert, Kapuaola S.
Heiss, Gerardo
Background: P wave indices and PR interval from 12-lead electrocardiograms (ECGs) are predictors of cardiovascular morbidity and mortality, but their repeatability has not been examined. Objectives: Determine the short-term repeatability of P wave indices (P axis, maximum P area and duration, P dispersion and P terminal force in V1) and PR interval. Methods: Participants (n = 63) underwent two standard ECGs at each of two visits, two weeks apart. We calculated the intra-class correlation coefficient (ICC), weighted kappa, and minimal detectable change and difference. Results: ICCs were 0.93 for PR interval, 0.78 for P axis, 0.77 for maximum P area, and 0.58 for maximum P duration. Within- and between-visit Kappa were 0.30 and 0.11 for P dispersion, and 0.68 and 0.46 for P terminal force. Conclusion: Repeatability of PR duration was excellent, that of P wave axis and maximum area was fair, and maximum P wave duration and terminal force was poor. Repeatability of P wave dispersion was fair within visit, yet poor between visits. These results illustrate potential biases when measurement error of some P wave indices is ignored in clinical and epidemiologic studies. (C) 2014 Elsevier Inc. All rights reserved.
Lima, Marize Concei=C3=A7=C3=A3o Ventin
Barbosa, Fernanda Ribeiro
Santos, Danielle Christine Moura dos
Nascimento, Raphaela Delmondes do
D=E2=80=99Azevedo, Stephanie Steremberg Pires
ABSTRACT OBJECTIVE To analyze the self-care practices on the face, hands and feet carried out by people affected by Hansen=E2=80=99s disease. METHODOLOGY A qualitative study, carried out in reference units for Hansen=E2=80=99s disease in Pernambuco, between May 2014 and April 2015, with 24 people. Data was collected through the semi-structured interview and content analysis was carried out. RESULTS Two categories emerged: Knowledge and execution of self-care practices in Leprosy and Singularities and challenges for self-care. The study found that respondents are familiar with information about face, hand and foot care, but report difficulties such as low income to acquire material for self-care, lack of time, and some lack of interest. Most of them already presented a degree of incapacity. CONCLUSIONS The training of professionals who work on the empowerment of people facing the disease, guidelines on prevention of disabilities and access to inputs for carrying out self-care are necessary.=09
Melo, Roberta Michelon
Dias, Roberta Freitas
Mota, Helena Bolli
Mezzomo, Carolina Lisb=C3=B4a
ABSTRACT The aim of this study was to analyze the ultrasound imaging of the tongue movement during the production of alveolar and velar stops, before and after speech therapy. A boy of a five year old and with Speech Disorder participated in this study. Were collected the articulatory data (ultrasound imaging of the tongue movement) and perceptive hearing of [t], [d], [k] and [g], before and after the 25 speech therapy sessions. Regarding results obtained in pre-therapy moment, when observing the three repetitions of the tongue curve of velar stops, a gestural indifferentiation was apparently detected, suggesting the presence of a dependency between the organizers of tip and body of the tongue. In the after therapy, a change in the tracing of the tongue gesture of [k] and [g] was verified. They started presenting a posteriorization of the tongue movement, synchronously with a rise in its body, as the adult standard. Thus, ultrasonographic findings were able to show a possible overcoming of the anteriorization stop velar, detected in the first perceptual speech analysis. In addition, these results seemed to reinforce the idea of covert contrasts in the speech of children with speech disorders.=09
Aoki, Y.
Motomura, Y.
Kawana, D.
Kikuchi, D.
Kuwahara, K.
Sato, H.
Substitution effect has been studied for the transition metal site on both of the metal-insulator transition in PrRu(4)P(12) and the anomalous nonmagnetic transition (probably of multipolar origin) in PrFe(4)P(12) by mutual alloying. It has been found that both of the transitions are significantly suppressed by the substitution. This observation supports the scenario that the expected Fermi-surface-nesting instability is an essential ingredient for both of the orderings. In the nonordered state, logarithmic temperature dependence in the electrical resistivity indicative of Kondo-like scatterings has been found only around the high Fe concentration, suggesting important roles of the Fe 3d electrons for the strongly correlated behavior. (c) 2006 Elsevier B.V. All rights reserved.
ABSTRACT With the aim of contributing to the discussions of politics and management of education in the school system, the text presents elements for the analysis of the possibilities of experiences of the democratic public school, through the alternation of theory and practice. To that end, we report the results of researches that analyzed dissertations, theses and articles published in periodicals about the democratic management theme. We also identified challenges for the area, searching for new conceptual horizons to understand the complexity of school educational management and, at last, we explore the concepts of =E2=80=9Cpolitics=E2=80=9D and =E2=80=9Cdemocracy=E2=80=9D through authors that allow us to rethink the relations between theory and practice present in the research commonly published in the area.=09
We present two case studies that illustrate how diverse yet complementary missions preventive action may achieve/offer in two different social contexts. The psychologist, while keeping in mind the objectives of prevention, guidance and emotional support, must adapt to the psychological and emotional characteristics of the mother. Intervening at home also requires a continuous adjustment from the psychologist in order to create a dynamic relationship with the patient and offers the possibility to observe from the inside the living conditions of the mother and her child. We apply the method of “research in action” to the story of Fatou, a teenage mother with a fragile narcissism, and that of Madeleine, young single mother of a premature infant, to show how the psychologist may work towards fostering the interactions between the mother and her baby, mitigating the possible risk of baby blues, and mobilising the resources that can be readily found in the psychological, social and family environment.
The compounds RuL(2)HX, where L = P(i)Pr(3) and X = Cl or N(SiMe(3))(2), are catalyst precursors for dimerization of terminal alkynes to enynes and also to cumulenes at 23 degrees C; selectivity among these products is X-dependent, but not high. Conversion of Ru species onto the catalytic cycle was undetectably small, so alternative approaches to understanding the catalytic mechanism were employed: stoichiometric reactions, independent synthesis of candidate intermediates, and trapping with CO. These show the intermediacy of vinylidenes and vinyl compounds, and reveal conversion of cumulenes to the thermodynamically more stable enynes. (C) 2007 Elsevier B.V. All rights reserved.
abstract Rorbeto is a polydactyl boy who beckons us and signals the presence of a different body in children's literature. Although in in the present time, various discourses and images, dialogues and characters are found in children's literature, the allusion to a different body in children's literature is still sparse or incomplete. Often, when this body appears in a literary work it can contribute to stereotypes and stigmas, which stem from cultural processes that contribute to the construction of corporal difference as a means of exclusion. The literary work Um garoto chamado Rorbeto (2005), written by Gabriel O Pensador, and illustrated by Daniel Bueno, includes another type of body, one that is larger and distinct from the normative body that traditionally appears in children=E2=80=99s literature. This body is a demanding body that is neither displaced nor demystified.=09
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