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Now showing items 17 - 21 of 21

  • Preparation, microstructure and properties of Al-Zn-Mg-Sc alloy tubes

    He Zhenbo   Yin Zhimin   Lin Sen   Deng Ying   Shang Baochuan   Zhou Xiang  

    The Al-6.0Zn-2.0Mg-0.2Sc-0.10Zr hollow tube ingots, prepared by semi-continuous casting technology, were subjected to homogenization treatment, hot extrusion, intermediate annealing, tension, solution and aging treatment. The microstructures and properties of as-cast Al-Zn-Mg-Sc alloy at different homogenization treatment conditions were studied using hardness measurement, X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. The results showed that the phases in the as-cast Al-Zn-Mg-Sc alloy were alpha(Al) and T(Mg(32)(Al,Zn)(49)). The metastable supersaturation solid solution decomposed firstly. Then the equilibrium T phases and dispersed Al(3)(Sc,Zr) particles precipitated and dissolved into the solution matrixes at high homogenization temperature. The appropriate homogenization processing was determined to be 470 C for 24 h. The microstructures after extrusion were non-recrystallized grains because of dispersed Al3(Sc, Zr) particles. After intermediate annealing most of the deformed microstructures were eliminated and softened. During solution treatment the equilibrium phases dissolved into the matrix, leading to the formation of supersaturation solid solution. The eta' phases precipitated from the solid solution during aging process. The eta' phases in the grain and the equilibrium phases on the grain boundaries were coarsening and the precipitate free zone (PFZ) was wider with increasing of the aging temperature and time. The suitable heat treatment for Al-Zn-Mg-Sc-Zr aluminum tubes was solution treated at 470 C for 1 h, followed by aging at 120 C for 24 h. At this condition, the ultimate tensile strength, yield strength and elongation could reach 520 MPa, 510 MPa and 11%, respectively. The high strength was mainly due to the fine grain strengthening caused by the addition of Sc and Zr, the subgrain strengthening and precipitation strengthening of Al3(Sc, Zr) particles and eta' phase.
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  • Natural compound curcumin corrects the gating defect of G551Dmutant cystic fibrosis transmembrane conductance regulator

    Hao Li-ming   Liu Xin   Xu Li-na   Zhu Na   Lin Sen   Hou Shu-guang   Zhou Na   Shi De-cheng   Shang De-jing   Ma Tong-hui   Yang Hong  

    In the present study, we identified the natural compound curcumin to bean effective G551D-CFTR activator by cell-based fluorescent assay and electrophysiological measurement. We demonstrated that curcumin can restore the impaired chloride conductance of G551D mutant CFTR. The activity is rapid, reversible, and cAMP-dependent. Our study identified a new natural lead compound for the pharmacological therapy of cystic fibrosis caused by G551D mutation of CFTR.
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  • Triphenyltin inhibition of the proteasome activity and its influence on substrate protein levels in nerve cells

    Chen Xi   Shi GuoQing   Zhong GuangRong   Chen Juan   Lin Sen   Sun Qing  

    Triphenyltin (TPT) widely exists as environmental pollutant, but its toxicity towards nerve cells and the related mechanism remain unclear. In this research, SHSY-5Y cells were exposed to TPT, and the cellular proteasome activity, I kappa b proteins, Bax and alpha-synuclein levels were investigated. The results show that TPT can inhibit the cellular proteasome activity, and result in the accumulation of ubiquitinized proteins. TPT exposure can change the protein levels of I kappa B, Bax, and alpha-synuclein, affect NF kappa B pathway, activate the process of cell death, and induce alpha-synuclein aggregation. Our results indicate that TPT exposure can lead to neuotoxicity.
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  • The Configuration of Fruit State Monitoring System Using the RFID System

    Ki Hwan Eom   N. T. T. Van   Lin Sen   Kyung Kwon Jung   Joo woong Kim  

    Fruit have a variety of vitamins and has the most vitamin C; and so we can know the status of the fruit to the loss of the vitamin C. There are a lot of factors that the loss of the vitamin C; but it is highly dependent on temperature. Therefore; monitoring temperature variability during transport and storage is very important. In this paper; we propose the fruit state monitoring system using the RFID system. The proposed system consists of server; RFID reader; RFID tag; sensor interface; temperature sensor. In order to verify the effectiveness of the proposed system; we performed experiments on the strawberry juice. Strawberry may be considered among the fruit most rich in Vitamin C. The temperature is taken by the sensor and reported through MFC software. Fruit state monitoring was divided into the 5 grade. The experimental results show that was confirmed the performance of the fruit state monitoring system.
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  • Ink drop and color distortion modeling in three dimensional printing

    Shi Tao   Lin Sen   Wang Hongpeng   Sun Lei   Liu Jingtai   Chen Xinwei  

    In this paper; the model of ink drop and color distortion is first proposed. At first; the ink drop fixing on three-dimensional and status change are analyzed and modeled. Based on this model; Author investigate the reason of color distortions in 3D printing; the parameters is obtained. Then; The range of printing angle and height of 3D model is developed. Finally; under the guidance of the model;the experiments prove that the algorithm is effective in three-dimensional printing.
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