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Now showing items 1 - 15 of 15

  • STEM CELL FILTERING SCREENING ENRICHMENT AND QUICKLY COMPOUNDING DEVICE

    A stem cell filtering screening enrichment and quickly compounding device, comprises a filter (1), a dual three-way board (2), an elongate pipe (3), a blood circulation driver (4) and a piece of porous material (5). The filter (1) includes a house (11) and a filtering box (12). The house (11) includes a shell (111) and a back cover (112) detachably connected with each other. The shell (111) is in a shape of a cylinder with a front bottom wall while the back cover (112) is in a shape of a cylinder with a back bottom wall, and each bottom wall individually has a hole (1110,1120) in its center; the filtering box (12), in a cylindrical shape, has a strainer-shaped box cover (121) and a strainer-shaped box bottom (122), and the inner chamber of the filtering box (12) is a volume-adjustable stem cell screening and enrichment chamber, furthermore the filtering box (12) is inserted into the back of the shell's chamber. The porous material (5) is disposed in the stem cell screening and enrichment chamber of the filtering box (12), and is matched in shape with the stem cell screening and enrichment chamber. Therefore, the compounding device enables acquiring marrow stem cells, which are highly enriched and compounded on material, during surgery without in vitro cell culture.
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  • Biological Sulfur Oxidation in Wastewater Treatment: A Review of Emerging Opportunities

    Lin Sen   Mackey Hamish R.   Hao Tianwei   Guo Gang   van Loosdrecht Mark C.M.   Chen Guanghao  

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  • IMAGE ROTATION METHOD AND SYSTEM FOR VIDEO PLAYER

    An image rotation method and an image rotation system for a video player are provided. The image rotation method includes the following steps. Firstly, an image rotation request from a terminal is received. Then, a source video file is decoded and a rotation processing operation is performed on the decoded source video file in response to the image rotation request, so that a rotated image of the source file is displayed. By the image rotation method and the image rotation system of the present invention, the image in the video player can be rotated by a specified angle. Consequently, the problems of the conventional video player will be overcome. Moreover, since the problems of causing the compressed and distorted image are eliminated, the quality of the played and displayed image is enhanced.
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  • The Formation and Stabilization of a Novel G-Quadruplex in the 5′-Flanking Region of the Relaxin Gene

    Lin Sen   Gu Huiping   Xu Ming   Cui Xiaojie   Zhang Youyi   Gao Wei   Yuan Gu   Isalan Mark  

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  • Bioinspired Design of Alcohol Dehydrogenase@nano TiO2 Microreactors for Sustainable Cycling of NAD+/NADH Coenzyme

    Lin Sen   Sun Shiyong   Wang Ke   Shen Kexuan   Ma Biaobiao   Ren Yuquan   Fan Xiaoyu  

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  • Microstructure, mechanical properties and stress corrosion behavior of friction stir welded joint of Al–Mg–Si alloy extrusion

    Lin Sen   Deng Yun-Lai   Lin Hua-Qiang   Ye Ling-Ying   Zhang Zhen   Ji Hua   Zhang Xin-Ming  

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  • Initial Decomposition of Methanol and Water on In2O3(110): A Periodic DFT Study

    Lin Sen   Xie Daiqian  

    Pure In2O3 is considered as an efficient methanol steam reforming catalyst. Despite of several studies in the past decades, the mechanism of MSR on In2O3 is still not fully understood. In this work, a periodic density functional theory study of the initial dissociation of methanol and water over the In2O3 (110) surface is presented. The activation energy barriers and thermochemistry for several elementary steps are reported. It is found that the energy barriers for O?H bond cleavage of both CH3OH and H2O to produce CH3O and OH species at a surface In-O pair site are very low, indicating that In2O3 (110) can facilely catalyze these two important processes at low temperatures. In addition, the subsequent dehydrogenation of CH3O to CH2O is also found to proceed with a low barrier.
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  • Neutrophil and Platelet to Lymphocyte Ratios in Associating with Blood Glucose Admission Predict the Functional Outcomes of Patients with Primary Brainstem Hemorrhage

    Zhang Fan   Li Hao   Tao Chuanyuan   Zheng Jun   Hu Xin   Lin Sen   Qian Juan   You Cao   Yang Mu  

    BACKGROUND: Because of a lack of markers for predicting prognosis and an underlying mechanism, patients with primary brainstem hemorrhage (PBH) are currently treated with multiple strategies, but most of them have poor outcomes in a comparison with patients with supratentorial intracranial hemorrhage. Recently, it has been reported that the neutrophil-to-lymphocyte ratio (NLR) represents a novel composite inflammatory marker to predict the prognosis of patients with intracranial hemorrhage, a majority of whom have supratentorial hemorrhage. In this report, we aim to assess the potential predictive value of NLR in patients with PBH. In addition, other available laboratory parameters, including platelet-to-lymphocyte ratio (PLR), and admission blood glucose level (ABG), will be also investigated as markers for prognosis in patients with PBH. METHODS: This study retrospectively enrolled 225 patients with acute PBH who were admitted West China Hospital from January 2012 to December 2016. ABG and absolute numbers of neutrophils, lymphocytes, white blood cells, and platelets were extracted from electronic medical records. ABG, NLR, and PLR were calculated and further assessed using multivariable logistic regression analysis for understanding the associations of treatment outcomes. The comparison of predictive power of independent predictors was evaluated using receiver operating characteristic. RESULTS: Of 225 inpatients, NLR (odds ratio [OR], 1.82; 95% confidence interval [CI]. 1.24 2.62, P< 0.01), PLR (OR, 1.43; 95% CI, 1.11 2.36; P =3D 0.013), and ABG (OR, 6.57; 95% CI, 2.78 15.52; P < 0.01) were independently associated with 90-day status in 112 patients with unfavorable outcomes. All 3 parameters also correlated with admission Glasgow Coma Scale score (r =3D -0.244, P < 0.001; r =3D -0.292, P < 0.001; r =3D -0.661, P < 0.01) and absolute neutrophil counts (r =3D 0.645, P < 0.001; r =3D 0.347, P < 0.001; r =3D 0.695, P < 0.01). Meanwhile, NLR exhibits a comparable predictive power by comparing with PLR (area under the curve [AUC], 0.694; 95%, CI, 0.626-0.764; P < 0.001; versus AUC, 0.662; 95% CI, 0.596-0.724; P < 0.001). In addition, ABG shows a positive predictive value (AUC, 0.784; 95% CI, 0.725 0.832; P < 0.001). The best independent predictive cutoff points were 6.65, 59.3, and 7.81 mmol/L for NLR, PLR, and ABG, respectively. Nevertheless, a combination of 3 parameters shows the best predictive ability (AUC, 0.835; 95% CI, 0.781-0.883; P < 0.001). CONCLUSIONS: NLR, PLR, and ABG can be used to independently predict 90-day functional outcome in patients after PBH. When combined, they have better predictive power in identifying PBH patients with a poor prognosis. To our knowledge, this study is the first to reveal the associations between NLR, PLR, and hyperglycemia and the functional outcomes of patient with PBH. In associating with previously studies on hemorrhage site, our results provide a good opportunity to elucidate the underlying mechanisms of PBH.
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  • Dictamine stimulates cystic fibrosis transmembrane conductance regulator Cl- transport

    Liu Jun   Liu Li-dan   Wang Su-mei   Xu Li-na   Yu Bo   Lin Sen   Hou Shu-guang   Zhou Na   Jin Ling-ling   Yang Hong  

    Dictamine is a furoquinoline alkaloid isolated from Dictamus dasycarpus Turcz. In the present study, we found that dictamine is able to stimulate the chloride transport activity of wild-type and Delta F508 mutant CFTR. The activity is cAMP-dependent and can he completely reversed by specific CFTR inhibitor CFTRinh-172. In addition, dictamine can further increase the chloride transport activity when CFTR is maximally activated by the combination of cAMP stimulators forskolin( FSK) and IBMX, suggesting direct interaction of dictamine with CFTR. Dictamine may be useful for probing CFTR channel gating mechanisms and used as a lead compound to develop the pharmacological therapy of CFTR-related diseases such as idiopathic chronic pancreatitis and keratoconjunctivitis sicca and cystic fibrosis.
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  • A simple method to extract tropical monsoon forests using NDVI based on MODIS data:A case study in South Asia and Peninsula Southeast Asia

    Lin Sen   Liu Ronggao  

    Distribution of monsoon forests is important for the research of carbon and water cycles in the tropical regions. In this paper, a simple approach is proposed to map monsoon forests using the Normalized Difference Vegetation Index (NDVI) derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) data. Owing to the high contrast of greenness between wet season and dry season, the monsoon forest can be easily discriminated from other forests by combining the maximum and minimum annual NDVI. The MODIS-based monsoon forest maps (MODMF) from 2000 to 2009 are derived and evaluated using the ground-truth dataset. The MODMF achieves an average producer accuracy of 80.0% and the Kappa statistic of 0.719. The variability of MODMF among different years is compared with that calculated from MODIS land cover products (MCD12Q1). The results show that the coefficient of variation of total monsoon forest area in MODMF is 7.3%, which is far lower than that in MCD12Q1 with 24.3%. Moreover, the pixels in MODMF which can be identified for 7 to 9 times between 2001 and 2009 account for 53.1%, while only 7.9% of MCD12Q1 pixels have this frequency. Additionally, the monsoon forest areas estimated in MODMF, Global Land Cover 2000 (GLC2000), MCD12Q1 and University of Maryland (UMD) products are compared with the statistical dataset at national level, which reveals that MODMF has the highest R (2) of 0.95 and the lowest RMSE of 14 014 km(2). This algorithm is simple but reliable for mapping the monsoon forests without complex classification techniques.
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  • Preparation, microstructure and properties of Al-Zn-Mg-Sc alloy tubes

    He Zhenbo   Yin Zhimin   Lin Sen   Deng Ying   Shang Baochuan   Zhou Xiang  

    The Al-6.0Zn-2.0Mg-0.2Sc-0.10Zr hollow tube ingots, prepared by semi-continuous casting technology, were subjected to homogenization treatment, hot extrusion, intermediate annealing, tension, solution and aging treatment. The microstructures and properties of as-cast Al-Zn-Mg-Sc alloy at different homogenization treatment conditions were studied using hardness measurement, X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. The results showed that the phases in the as-cast Al-Zn-Mg-Sc alloy were alpha(Al) and T(Mg(32)(Al,Zn)(49)). The metastable supersaturation solid solution decomposed firstly. Then the equilibrium T phases and dispersed Al(3)(Sc,Zr) particles precipitated and dissolved into the solution matrixes at high homogenization temperature. The appropriate homogenization processing was determined to be 470 C for 24 h. The microstructures after extrusion were non-recrystallized grains because of dispersed Al3(Sc, Zr) particles. After intermediate annealing most of the deformed microstructures were eliminated and softened. During solution treatment the equilibrium phases dissolved into the matrix, leading to the formation of supersaturation solid solution. The eta' phases precipitated from the solid solution during aging process. The eta' phases in the grain and the equilibrium phases on the grain boundaries were coarsening and the precipitate free zone (PFZ) was wider with increasing of the aging temperature and time. The suitable heat treatment for Al-Zn-Mg-Sc-Zr aluminum tubes was solution treated at 470 C for 1 h, followed by aging at 120 C for 24 h. At this condition, the ultimate tensile strength, yield strength and elongation could reach 520 MPa, 510 MPa and 11%, respectively. The high strength was mainly due to the fine grain strengthening caused by the addition of Sc and Zr, the subgrain strengthening and precipitation strengthening of Al3(Sc, Zr) particles and eta' phase.
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  • Natural compound curcumin corrects the gating defect of G551Dmutant cystic fibrosis transmembrane conductance regulator

    Hao Li-ming   Liu Xin   Xu Li-na   Zhu Na   Lin Sen   Hou Shu-guang   Zhou Na   Shi De-cheng   Shang De-jing   Ma Tong-hui   Yang Hong  

    In the present study, we identified the natural compound curcumin to bean effective G551D-CFTR activator by cell-based fluorescent assay and electrophysiological measurement. We demonstrated that curcumin can restore the impaired chloride conductance of G551D mutant CFTR. The activity is rapid, reversible, and cAMP-dependent. Our study identified a new natural lead compound for the pharmacological therapy of cystic fibrosis caused by G551D mutation of CFTR.
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  • Establishment of Recombinase Polymerase Amplification for Rapid Detection of Spring Viremia of Carp Virus(SVCV)

    Liang Junni   Yin Weili   Shang Di   Liu Ning   Duan Xiaohui   Lin Sen  

    [Objective] The paper was to develop a rapid method for the detection of spring Viremia of carp virus(SVCV). [Method] The specific primers were designed by targeting the G gene of SVCV. The recombinase polymerase amplification(RPA) assay for detecting SVCV was estab-lished by optimizing the reaction conditions. The optimal amplification temperature of RPA assay was 30 ℃, and the test could be finished within 20 min. [Result] The method was specific with no cross-reaction with other common fish infectious viruses. Sensitivity test showed that the lowest detection limit of the method was 89.2 copies/μL, higher than that of traditional RT-PCR. Moreover, a total of 80 clinical samples were detected by RPA and RT-PCR, respectively. The weak positive samples tested by RT-PCR could be detectable with RPA, indicating that RPA assay could be used in clinical detection. [Conclusion] The method established is rapid, simple, specific and sensitive for testing SVCV, and it will be widely used in grassroots laboratory and on-site inspection.
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  • The Configuration of Fruit State Monitoring System Using the RFID System

    Ki Hwan Eom   N. T. T. Van   Lin Sen   Kyung Kwon Jung   Joo woong Kim  

    Fruit have a variety of vitamins and has the most vitamin C; and so we can know the status of the fruit to the loss of the vitamin C. There are a lot of factors that the loss of the vitamin C; but it is highly dependent on temperature. Therefore; monitoring temperature variability during transport and storage is very important. In this paper; we propose the fruit state monitoring system using the RFID system. The proposed system consists of server; RFID reader; RFID tag; sensor interface; temperature sensor. In order to verify the effectiveness of the proposed system; we performed experiments on the strawberry juice. Strawberry may be considered among the fruit most rich in Vitamin C. The temperature is taken by the sensor and reported through MFC software. Fruit state monitoring was divided into the 5 grade. The experimental results show that was confirmed the performance of the fruit state monitoring system.
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  • Ink drop and color distortion modeling in three dimensional printing

    Shi Tao   Lin Sen   Wang Hongpeng   Sun Lei   Liu Jingtai   Chen Xinwei  

    In this paper; the model of ink drop and color distortion is first proposed. At first; the ink drop fixing on three-dimensional and status change are analyzed and modeled. Based on this model; Author investigate the reason of color distortions in 3D printing; the parameters is obtained. Then; The range of printing angle and height of 3D model is developed. Finally; under the guidance of the model;the experiments prove that the algorithm is effective in three-dimensional printing.
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