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Now showing items 1 - 16 of 21

  • Shell buckling: from morphogenesis of soft matters to prospective applications

    Lin Sen   Xie Yi Min   Li Qing   Huang Xiaodong   Zhang Zhe   Ma Guowei   Zhou Shiwei  

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    A stem cell filtering screening enrichment and quickly compounding device, comprises a filter (1), a dual three-way board (2), an elongate pipe (3), a blood circulation driver (4) and a piece of porous material (5). The filter (1) includes a house (11) and a filtering box (12). The house (11) includes a shell (111) and a back cover (112) detachably connected with each other. The shell (111) is in a shape of a cylinder with a front bottom wall while the back cover (112) is in a shape of a cylinder with a back bottom wall, and each bottom wall individually has a hole (1110,1120) in its center; the filtering box (12), in a cylindrical shape, has a strainer-shaped box cover (121) and a strainer-shaped box bottom (122), and the inner chamber of the filtering box (12) is a volume-adjustable stem cell screening and enrichment chamber, furthermore the filtering box (12) is inserted into the back of the shell's chamber. The porous material (5) is disposed in the stem cell screening and enrichment chamber of the filtering box (12), and is matched in shape with the stem cell screening and enrichment chamber. Therefore, the compounding device enables acquiring marrow stem cells, which are highly enriched and compounded on material, during surgery without in vitro cell culture.
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  • Transformation of Litchi Pericarp-Derived Condensed Tannin with Aspergillus awamori

    Lin Sen   Li Qing   Yang Bao   Duan Xuewu   Zhang Mingwei   Shi John   Jiang Yueming  

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  • Biological Sulfur Oxidation in Wastewater Treatment: A Review of Emerging Opportunities

    Lin Sen   Mackey Hamish R.   Hao Tianwei   Guo Gang   van Loosdrecht Mark C.M.   Chen Guanghao  

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    An image rotation method and an image rotation system for a video player are provided. The image rotation method includes the following steps. Firstly, an image rotation request from a terminal is received. Then, a source video file is decoded and a rotation processing operation is performed on the decoded source video file in response to the image rotation request, so that a rotated image of the source file is displayed. By the image rotation method and the image rotation system of the present invention, the image in the video player can be rotated by a specified angle. Consequently, the problems of the conventional video player will be overcome. Moreover, since the problems of causing the compressed and distorted image are eliminated, the quality of the played and displayed image is enhanced.
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  • Molecular evolution ofpsbAgene in ferns: unraveling selective pressure and co-evolutionary pattern

    Lin Sen   Mario Fares   Ying-Juan Su   Ting Wang  

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  • Molecular evolution ofrbcLin three gymnosperm families: identifying adaptive and coevolutionary patterns

    Lin Sen   Mario A Fares   Bo Liang   Lei Gao   Bo Wang   Ting Wang   Ying-Juan Su  

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  • Bioinspired Design of Alcohol Dehydrogenase@nano TiO2 Microreactors for Sustainable Cycling of NAD+/NADH Coenzyme

    Lin Sen   Sun Shiyong   Wang Ke   Shen Kexuan   Ma Biaobiao   Ren Yuquan   Fan Xiaoyu  

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  • Microstructure, mechanical properties and stress corrosion behavior of friction stir welded joint of Al–Mg–Si alloy extrusion

    Lin Sen   Deng Yun-Lai   Lin Hua-Qiang   Ye Ling-Ying   Zhang Zhen   Ji Hua   Zhang Xin-Ming  

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  • Variations in eco-enzymatic stoichiometric and microbial characteristics in paddy soil as affected by long-term integrated organic-inorganic fertilization

    Lin Sen   Wang Shaoxian   Si Yuanli   Yang Wenhao   Zhu Shaowei   Ni Wuzhong   Paz-Ferreiro Jorge  

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  • Forest Fungi Phytogeography: Forest Fungi Phytogeography of China, North America, and Siberia, and International Quarantine of Tree Pathogens = Sen lin zhenjun bing li di liby Mo Mei Chen

    Review by: Rudolf Schmid  

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  • Neutrophil and Platelet to Lymphocyte Ratios in Associating with Blood Glucose Admission Predict the Functional Outcomes of Patients with Primary Brainstem Hemorrhage

    Zhang Fan   Li Hao   Tao Chuanyuan   Zheng Jun   Hu Xin   Lin Sen   Qian Juan   You Cao   Yang Mu  

    BACKGROUND: Because of a lack of markers for predicting prognosis and an underlying mechanism, patients with primary brainstem hemorrhage (PBH) are currently treated with multiple strategies, but most of them have poor outcomes in a comparison with patients with supratentorial intracranial hemorrhage. Recently, it has been reported that the neutrophil-to-lymphocyte ratio (NLR) represents a novel composite inflammatory marker to predict the prognosis of patients with intracranial hemorrhage, a majority of whom have supratentorial hemorrhage. In this report, we aim to assess the potential predictive value of NLR in patients with PBH. In addition, other available laboratory parameters, including platelet-to-lymphocyte ratio (PLR), and admission blood glucose level (ABG), will be also investigated as markers for prognosis in patients with PBH. METHODS: This study retrospectively enrolled 225 patients with acute PBH who were admitted West China Hospital from January 2012 to December 2016. ABG and absolute numbers of neutrophils, lymphocytes, white blood cells, and platelets were extracted from electronic medical records. ABG, NLR, and PLR were calculated and further assessed using multivariable logistic regression analysis for understanding the associations of treatment outcomes. The comparison of predictive power of independent predictors was evaluated using receiver operating characteristic. RESULTS: Of 225 inpatients, NLR (odds ratio [OR], 1.82; 95% confidence interval [CI]. 1.24 2.62, P< 0.01), PLR (OR, 1.43; 95% CI, 1.11 2.36; P =3D 0.013), and ABG (OR, 6.57; 95% CI, 2.78 15.52; P < 0.01) were independently associated with 90-day status in 112 patients with unfavorable outcomes. All 3 parameters also correlated with admission Glasgow Coma Scale score (r =3D -0.244, P < 0.001; r =3D -0.292, P < 0.001; r =3D -0.661, P < 0.01) and absolute neutrophil counts (r =3D 0.645, P < 0.001; r =3D 0.347, P < 0.001; r =3D 0.695, P < 0.01). Meanwhile, NLR exhibits a comparable predictive power by comparing with PLR (area under the curve [AUC], 0.694; 95%, CI, 0.626-0.764; P < 0.001; versus AUC, 0.662; 95% CI, 0.596-0.724; P < 0.001). In addition, ABG shows a positive predictive value (AUC, 0.784; 95% CI, 0.725 0.832; P < 0.001). The best independent predictive cutoff points were 6.65, 59.3, and 7.81 mmol/L for NLR, PLR, and ABG, respectively. Nevertheless, a combination of 3 parameters shows the best predictive ability (AUC, 0.835; 95% CI, 0.781-0.883; P < 0.001). CONCLUSIONS: NLR, PLR, and ABG can be used to independently predict 90-day functional outcome in patients after PBH. When combined, they have better predictive power in identifying PBH patients with a poor prognosis. To our knowledge, this study is the first to reveal the associations between NLR, PLR, and hyperglycemia and the functional outcomes of patient with PBH. In associating with previously studies on hemorrhage site, our results provide a good opportunity to elucidate the underlying mechanisms of PBH.
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  • Molecular evolution of rbcL in three gymnosperm families: identifying adaptive and coevolutionary patterns

    Lin Sen   Mario A Fares   Bo Liang   Lei Gao   Bo Wang   Ting Wang   Ying-Juan Su  

    BackgroundThe chloroplast-localized ribulose-1, 5-biphosphate carboxylase/oxygenase (Rubisco), the primary enzyme responsible for autotrophy, is instrumental in the continual adaptation of plants to variations in the concentrations of CO2. The large subunit (LSU) of Rubisco is encoded by the chloroplast rbcL gene. Although adaptive processes have been previously identified at this gene, characterizing the relationships between the mutational dynamics at the protein level may yield clues on the biological meaning of such adaptive processes. The role of such coevolutionary dynamics in the continual fine-tuning of RbcL remains obscure.ResultsWe used the timescale and phylogenetic analyses to investigate and search for processes of adaptive evolution in rbcL gene in three gymnosperm families, namely Podocarpaceae, Taxaceae and Cephalotaxaceae. To understand the relationships between regions identified as having evolved under adaptive evolution, we performed coevolutionary analyses using the software CAPS. Importantly, adaptive processes were identified at amino acid sites located on the contact regions among the Rubisco subunits and on the interface between Rubisco and its activase. Adaptive amino acid replacements at these regions may have optimized the holoenzyme activity. This hypothesis was pinpointed by evidence originated from our analysis of coevolution that supported the correlated evolution between Rubisco and its activase. Interestingly, the correlated adaptive processes between both these proteins have paralleled the geological variation history of the concentration of atmospheric CO2.ConclusionsThe gene rbcL has experienced bursts of adaptations in response to the changing concentration of CO2 in the atmosphere. These adaptations have emerged as a result of a continuous dynamic of mutations, many of which may have involved innovation of functional Rubisco features. Analysis of the protein structure and the functional implications of such mutations put forward the conclusion that this evolutionary scenario has been possible through a complex interplay between adaptive mutations, often structurally destabilizing, and compensatory mutations. Our results unearth patterns of evolution that have likely optimized the Rubisco activity and uncover mutational dynamics useful in the molecular engineering of enzymatic activities.ReviewersThis article was reviewed by Prof. Christian Blouin (nominated by Dr W Ford Doolittle), Dr Endre Barta (nominated by Dr Sandor Pongor), and Dr Nicolas Galtier.
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  • Ink Drop and Color Distortion Modeling in Three Dimensional Printing

    Chen Xinwei   Liu Jingtai   Sun Lei   Wang Hongpeng   Lin Sen   Shi Tao  

    In this paper, the model of ink drop and color distortion is first proposed. At first, the ink drop fixing on three-dimensional and status change are analyzed and modeled. Based on this model, Author investigate the reason of color distortions in 3D printing, the parameters is obtained. Then, The range of printing angle and height of 3D model is developed. Finally, under the guidance of the model, the experiments prove that the algorithm is effective in three-dimensional printing.
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  • Dictamine stimulates cystic fibrosis transmembrane conductance regulator Cl- transport

    Liu Jun   Liu Li-dan   Wang Su-mei   Xu Li-na   Yu Bo   Lin Sen   Hou Shu-guang   Zhou Na   Jin Ling-ling   Yang Hong  

    Dictamine is a furoquinoline alkaloid isolated from Dictamus dasycarpus Turcz. In the present study, we found that dictamine is able to stimulate the chloride transport activity of wild-type and Delta F508 mutant CFTR. The activity is cAMP-dependent and can he completely reversed by specific CFTR inhibitor CFTRinh-172. In addition, dictamine can further increase the chloride transport activity when CFTR is maximally activated by the combination of cAMP stimulators forskolin( FSK) and IBMX, suggesting direct interaction of dictamine with CFTR. Dictamine may be useful for probing CFTR channel gating mechanisms and used as a lead compound to develop the pharmacological therapy of CFTR-related diseases such as idiopathic chronic pancreatitis and keratoconjunctivitis sicca and cystic fibrosis.
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  • A simple method to extract tropical monsoon forests using NDVI based on MODIS data:A case study in South Asia and Peninsula Southeast Asia

    Lin Sen   Liu Ronggao  

    Distribution of monsoon forests is important for the research of carbon and water cycles in the tropical regions. In this paper, a simple approach is proposed to map monsoon forests using the Normalized Difference Vegetation Index (NDVI) derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) data. Owing to the high contrast of greenness between wet season and dry season, the monsoon forest can be easily discriminated from other forests by combining the maximum and minimum annual NDVI. The MODIS-based monsoon forest maps (MODMF) from 2000 to 2009 are derived and evaluated using the ground-truth dataset. The MODMF achieves an average producer accuracy of 80.0% and the Kappa statistic of 0.719. The variability of MODMF among different years is compared with that calculated from MODIS land cover products (MCD12Q1). The results show that the coefficient of variation of total monsoon forest area in MODMF is 7.3%, which is far lower than that in MCD12Q1 with 24.3%. Moreover, the pixels in MODMF which can be identified for 7 to 9 times between 2001 and 2009 account for 53.1%, while only 7.9% of MCD12Q1 pixels have this frequency. Additionally, the monsoon forest areas estimated in MODMF, Global Land Cover 2000 (GLC2000), MCD12Q1 and University of Maryland (UMD) products are compared with the statistical dataset at national level, which reveals that MODMF has the highest R (2) of 0.95 and the lowest RMSE of 14 014 km(2). This algorithm is simple but reliable for mapping the monsoon forests without complex classification techniques.
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