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Now showing items 97 - 112 of 21269

  • Role of Osteoblast G(i) Signaling in Age-Related Bone Loss in Female Mice

    Millard, Susan M.   Wang, Liping   Wattanachanya, Lalita   O'Carroll, Dylan   Fields, Aaron J.   Pang, Joyce   Kazakia, Galateia   Lotz, Jeffrey C.   Nissenson, Robert A.  

    Age-related bone loss is an important risk factor for fractures in the elderly; it results from an imbalance in bone remodeling mainly due to decreased bone formation. We have previously demonstrated that endogenous G protein-coupled receptor (GPCR)-driven Gi signaling in osteoblasts (Obs) restrains bone formation in mice during growth. Here, we launched a longitudinal study to test the hypothesis that G(i) signaling in Obs restrains bone formation in aging mice, thereby promoting bone loss. Our approach was to block G(i) signaling in maturing Obs by the induced expression of the catalytic subunit of pertussis toxin (PTX) after the achievement of peak bone mass. In contrast to the progressive cancellous bone loss seen in aging sex-matched littermate control mice, aging female Col1(2.3)(+)/PTX+ mice showed an age-related increase in bone volume. Increased bone volume was associated with increased bone formation at both trabecular and endocortical surfaces as well as increased bending strength of the femoral middiaphyses. In contrast, male Col1 (2.3)(+)/PTX+ mice were not protected from age-related bone loss. Our results indicate that G(i) signaling markedly restrains bone formation at cancellous and endosteal bone surfaces in female mice during aging. Blockade of the relevant G(i)-coupled GPCRs represents an approach for the development of osteoporosis therapies-at least in the long bones of aging women.
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  • [Nr 29] Radioterapia adaptacyjna nowotworów g?owy i szyi

    Piotrowski   Tomasz  

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  • G. I. Gurdjieff’s Piano Music and Its Application in and outside “The Work”

    Petsche, Johanna J. M.  

    Gurdjieff (c. 1866-1949) wrote a diverse collection of piano pieces at his "Institute for the Harmonious Development of Man" at the Chateau du Prieur d'Avon at Fontainebleau near Paris in a unique collaboration with pupil Thomas de Hartmann, a Ukrainian composer. This music was composed most intensely between the years 1925 and 1927, after Gurdjieff's near-fatal car accident of 1924 when all work on his "Movements" or "sacred dances" had ceased. Thus this music was not written for the Movements but for other spiritual purposes. Gurdjieff would whistle, sing, and tap Eastern-sounding melodies and rhythms, and de Hartmann was required to immediately transform these indications into written Western notation, adding suitable harmonies. Like Gurdjieff's teaching overall, the piano music is best described as a blending of Eastern and Western elements. In Gurdjieff's lifetime this music was not published or recorded, and was mostly performed within his circle of pupils, as is appropriate within an initiatory and personally transmitted spiritual teaching. This article explores the Gurdjieff-de Hartmann music and its relationship to Gurdjieff's overall esoteric teachings. There will also be an examination of how Gurdjieff groups and musicians continue to keep alive this music today, and it will be shown that the large number of recordings released represent its greatest cultural penetration into wider society. Currently hundreds of these recordings are available though, interestingly, most "Work" members are critical of them, arguing that the music only has value when experienced live and in a Work context.
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  • I G Petrochemicals Limited 24th Annual Report 2012-13

    MM Dhanuka  

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  • H. G. Wells: Interdisciplinary Essays (review)

    Genie Babb,  

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  • g\r factor of boron-like ions: ground and excited states

    Glazov, D A   Volotka, A V   Schepetnov, A A   Sokolov, M M   Shabaev, V M   Tupitsyn, I I   Plunien, G  

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  • Pourazowe zmiany krtani i g?osu u dzieci

    Wojnowski, Waldemar   Wiskirska-Wo?nica, Bo?ena   Obr?bowski, Andrzej   Czerniejewska, Hanna  

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  • Ya. G. Sinai: Selecta, Volumes I and II

    Domokos Szász  

    The article reviews the books "Selecta: Ergodic Theory and Dynamical Systems," Volume I and "Selecta: Probability, Statistical Mechanics, Mathematical Physics and Mathematical Fluid Dynamics," Volume II, by Ya G. Sinai.
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  • Shakespearean Vertigo: W. G. Sebald's Lear

    Anita Gilman Sherman,  

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  • G. I. Gurdjieff’s Piano Music and Its Application in and outside “The Work”

    Petsche   Johanna J. M.  

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  • Emerging Teachers and Globalisation. By G. Czerniawski

    Jones, Marion  

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  • Finding Dense Subgraphs in G(n,1/2)

    Atish Das Sarma, Amit Deshpande   Ravi Kannan  

    Finding the largest clique in random graphs is a well known hard problem. It is known that a random graph G(n, 1/2) almost surely has a clique of size about 2logn. A simple greedy algorithm finds a clique of size logn, and it is a long-standing open problem to find a clique of size (1 + ε)logn in randomized polynomial time. In this paper, we study the generalization of finding the largest subgraph of any given edge density. We show that a simple modification of the greedy algorithm finds a subset of 2logn vertices with induced edge density at least 0.951. We also show that almost surely there is no subset of 2.784logn vertices whose induced edge density is at least 0.951.
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  • In Memoriam G. Alan Marlatt 1941–2011

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  • Homogenization and Enhancement for the G—Equation

    We consider the so-called G-equation, a level set Hamilton–Jacobi equation used as a sharp interface model for flame propagation, perturbed by an oscillatory advection in a spatio-temporal periodic environment. Assuming that the advection has suitably small spatial divergence, we prove that, as the size of the oscillations diminishes, the solutions homogenize (average out) and converge to the solution of an effective anisotropic first-order (spatio-temporal homogeneous) level set equation. Moreover, we obtain a rate of convergence and show that, under certain conditions, the averaging enhances the velocity of the underlying front. We also prove that, at scale one, the level sets of the solutions of the oscillatory problem converge, at long times, to the Wulff shape associated with the effective Hamiltonian. Finally, we also consider advection depending on position at the integral scale.
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  • In Memoriam G. Alan Marlatt 1941–2011

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  • G(1,1,λ,ρ) Optimization Model and Application Based on the FS

    Wang, Han Lin; Ren, Zi Hui; Xue, Li Xia; Luo, Yan Li  

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