Joshi, Amit | onAcademic

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journal(165)

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joshi, amit(169)

prabhash, kumar(37)

noronha, vanita(36)

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oral oncology(5)

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Organization

Now showing items 1 - 16 of 170

Study on wetting and dispersion of the Pigment Yellow 110

Nagose, Swati Rose, Elvina Joshi, Amit

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PHOTOACTIVATABLE LIPID-BASED NANOPARTICLES AS VEHICLES FOR DUAL AGENT DELIVERY

Embodiments of photoactivatable, lipid-based nanoparticles are disclosed, as well as methods of making and using the nanoparticles. Pharmaceutical compositions including the nanoparticles also are disclosed. The lipid-based nanoparticles include a vesicle wall surrounding a cavity, wherein the vesicle wall includes (i) a lipid bilayer comprising 1,2-bis(tricosa- 10,12- diynoyl)-sn-glycero-3-phosphocholine (DC8,9PC), dipalmitoylphosphatidylcholine (DPPC), and (ii) 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) within the lipid bilayer. The nanoparticles may further include an agent within the cavity.

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ROS1 mutation non-small cell lung cancer—access to optimal treatment and outcomes

Joshi, Amit Pande, Nikhil Noronha, Vanita Patil, Vijay Kumar, Rajiv Chougule, Anuradha Vaishakhi, Trivedi Janu, Amit Mahajan, Abhishek Prabhash, Kumar

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The Prognostic Value of Initial Tumor Size in Patients with Ewing Family of Tumors

Deo, Rajeeb Kumar Chitalkar, Prakash Joshi, Amit Ranamagar, Sushil

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The Direct and Indirect Effects of Advertising Spending on Firm Value

Joshi, Amit Hanssens, Dominique M

Marketing decision makers are increasingly aware of the importance of shareholder value maximization, which calls for an evaluation of the long-term effects of their actions on product-market response and investor response. However, the marketing literature to date has focused on the sales or profit response of marketing actions, and the goals of marketing have traditionally been formulated from a customer perspective. Recently, there have been a few studies of the long-term investor response to marketing actions. The current research investigates one important aspect of this impact, the long-term relationship between advertising spending and market capitalization. The authors hypothesize that advertising can have a direct effect on valuation (i.e., an effect beyond its indirect effect through sales revenue and profit response). The empirical results across two industries provide support for the hypothesis that advertising spending has a positive, long-term impact on own firms' market capitalization and may have a negative impact on the valuation of a competitor of comparable size. The authors quantify the magnitude of this investor response effect for and discuss its implications for further research.

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Urine Exosomal Ceruloplasmin a Potential Early Biomarker of Underlying Kidney Disease

Gudehithlu, Krishnamurthy P Hart, Peter Joshi, Amit Garcia-Gomez, Ignacio Cimbaluk, David J Dunea, George L Arruda, Jose A Singh, Ashok K

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Structure-Based Design of a Heptavalent Anthrax Toxin Inhibitor

Joshi, Amit Kate, Sandesh Poon, Vincent Mondal, Dhananjoy Boggara, Mohan B. Saraph, Arundhati Martin, Jacob T. McAlpine, Ryan Day, Ryan Garcia, Angel E. Mogridge, Jeremy Kane, Ravi S.

The design of polyvalent molecules, consisting of multiple copies of a biospecific ligand attached to a suitable scaffold, represents a promising approach to inhibit pathogens and oligomeric microbial toxins. Despite the increasing interest in structure-based drug design, few polyvalent inhibitors based on this approach have shown efficacy in vivo. Here we demonstrate the structure-based design of potent biospecific heptavalent inhibitors of anthrax lethal toxin. Specifically, we illustrate the ability to design potent polyvalent ligands by matching the pattern of binding sites on the biological target. We used a combination of experimental studies based on mutagenesis and computational docking studies to identify the binding site for an inhibitory peptide on the heptameric subunit of anthrax toxin. We developed an approach based on copper-catalyzed azide-alkyne cycloaddition (click-chemistry) to facilitate the attachment of seven copies of the inhibitory peptide to a beta-cyclodextrin core via a polyethylene glycol linker of an appropriate length. The resulting heptavalent inhibitors neutralized anthrax lethal toxin both in vitro and in vivo and showed appreciable stability in serum. Given the inherent biocompatibility of cyclodextrin and polyethylene glycol, these potent well-defined heptavalent inhibitors show considerable promise as anthrax antitoxins.

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Urine exosomal ceruloplasmin: a potential early biomarker of underlying kidney disease

Gudehithlu, Krishnamurthy P. Hart, Peter Joshi, Amit Garcia-Gomez, Ignacio Cimbaluk, David J. Dunea, George Arruda, Jose A. L. Singh, Ashok K.

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Neutron-shielding behaviour investigations of some clay-materials

Olukotun, S.F. Mann, Kulwinder Singh Gbenu, S.T. Ibitoye, F.I. Oladejo, O.F. Joshi, Amit Tekin, H.O. Sayyed, M.I. Fasasi, M.K. Balogun, F.A. Korkut, Turgay

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Cutaneous Penetration Enhancing Effect of Menthol: Calcium Involvement

Joshi, Amit Joshi, Abhay Patel, Hiren Ponnoth, Dovenia Stagni, Grazia

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Riots After Medical Mishaps. How can we Improve?

Joshi, Amit

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Comparative pharmacognostical and phytochemical evaluation of two species of Cyathocline

Gupta, Ashwini Joshi, Amit Dubey, Balkrishna

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TGF-ß signaling, tumor microenvironment and tumor progression: the butterfly effect

Joshi, Amit

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Improved Excitation Light Rejection Enhances Small-Animal Fluorescent Optical Imaging

Hwang, Kildong Houston, Jessica P. Rasmussen, John C. Joshi, Amit Ke, Shi Li, Chun Sevick-Muraca, Eva M.

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Adaptive finite element based tomography for fluorescence optical imaging in tissue

Joshi, Amit Bangerth, Wolfgang Sevick-Muraca, Eva M.

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Plane-wave fluorescence tomography with adaptive finite elements

Joshi, Amit Bangerth, Wolfgang Hwang, Kildong Rasmussen, John Sevick-Muraca, Eva M.

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Study on wetting and dispersion of the Pigment Yellow 110

PHOTOACTIVATABLE LIPID-BASED NANOPARTICLES AS VEHICLES FOR DUAL AGENT DELIVERY

ROS1 mutation non-small cell lung cancer—access to optimal treatment and outcomes

The Prognostic Value of Initial Tumor Size in Patients with Ewing Family of Tumors

The Direct and Indirect Effects of Advertising Spending on Firm Value

Urine Exosomal Ceruloplasmin a Potential Early Biomarker of Underlying Kidney Disease

Structure-Based Design of a Heptavalent Anthrax Toxin Inhibitor

Urine exosomal ceruloplasmin: a potential early biomarker of underlying kidney disease

Neutron-shielding behaviour investigations of some clay-materials

Cutaneous Penetration Enhancing Effect of Menthol: Calcium Involvement

Riots After Medical Mishaps. How can we Improve?

Comparative pharmacognostical and phytochemical evaluation of two species of Cyathocline

TGF-ß signaling, tumor microenvironment and tumor progression: the butterfly effect

Improved Excitation Light Rejection Enhances Small-Animal Fluorescent Optical Imaging

Adaptive finite element based tomography for fluorescence optical imaging in tissue

Plane-wave fluorescence tomography with adaptive finite elements

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