Creat membership Creat membership
Sign in

Forgot password?

  • Forgot password?
    Sign Up
  • Confirm
    Sign In
home > search

Now showing items 1 - 16 of 135

  • A Two-Photon Fluorescent Probe for Lysosomal Thiols in Live Cells and Tissues

    Fan, Jiangli   Han, Zhichao   Kang, Yao   Peng, Xiaojun  

    Download Collect

    Disclosed are boron-dipyrromethene fluorescence probes with a structure as shown in Formula I below, and a manufacturing method and use thereof. The boron-dipyrromethene fluorescence probes have low background fluorescence, and following the addition of hypochloric acid is a fast and significant fluorescence enhancement, and the fluorescence intensity after the fluorescence enhancement is up to 100 times as much as that before the fluorescence enhancement; there is a sound linear relation between the fluorescence intensity of the probes and the concentration of hypochloric acid in a nanomole range, with the limit of detection of 0.56 nanomoles; the probes have a good selectivity, hardly respond to other active oxygen substances, such as H2O2, O2 -, TBHP (tert-butyl hydroperoxide), HO·, TBO·, 1O2 and NO·, and are free from pH interferences in a wide range; the probes can be applied to detecting hypochloric acid in living cells.
    Download Collect
  • An ICT-based ratiometric probe for hydrazine and its application in live cells

    Fan, Jiangli   Sun, Wen   Hu, Mingming   Cao, Jianfang   Cheng, Guanghui   Dong, Huijuan   Song, Kedong   Liu, Yingchao   Sun, Shiguo   Peng, Xiaojun  

    Hydrazine is an important industrial chemical but also very toxic thus requiring rapid detection agents. A ratiometric fluorescence probe that enables rapid, low-limit and naked-eye detection is successfully designed and used for hydrazine determination in live cells.
    Download Collect
  • A fluorescent probe for site I binding and sensitive discrimination of HSA from BSA

    Fan, Jiangli   Sun, Wen   Wang, Zhenkuan   Peng, Xiaojun   Li, Yueqing   Cao, Jianfang  

    A fluorescent probe DH1 has been successfully developed to detect HSA via site I non-covalent bonding. DH1 shows a dramatic fluorescence enhancement towards HSA without interference from other proteins. The molecular docking method, for the first time, was utilized to provide deep insight into the sensing mechanism of the probe. Moreover, probe DH1 was successfully used to detect trace HSA in healthy human urine.
    Download Collect

    A fluorescent probe and its combination are disclosed. They have excitation and emission wavelengths within visible range, high sensitivity, and good selectivity for mercury ion when pH is 5-12, and can be used to detect mercury ion in water sample. There is no interference of Na, K, Ca, Mg, Cu, chloride, nitrate and sulfate ions for the detection. In ethanol-HEPES buffer solution, the ion concentration and fluorescence intensity are in good linear relation within mercury ion concentration of 2-12 ppb.
    Download Collect
  • A ratiometric lysosomal pH chemosensor based on fluorescence resonance energy transfer

    Fan, Jiangli   Lin, Chunying   Li, Honglin   Zhan, Peng   Wang, Jingyun   Cui, Shuang   Hu, Mingming   Cheng, Guanghui   Peng, Xiaojun  

    In this work, we presented a naphthalimide-rhodamine based fluorescence resonance energy transfer system (FRET) NR1 as a ratiometric and intracellular pH probe, in which 1,2,3-triazole was identified as an ideal bridge and biocompatibility. It could selectively monitor pH variations in methanol/HEPES solution at room temperature. When the pH changed from 6.20 to 2.00, both the fluorescence intensities at 580 nm and the intensity ratios, R ( I580 nm/ I538 nm) increased, which allowed the detection of pH changes by both normal fluorescence and ratiometric fluorescence methods. The observation is consistent with the increased FRET from the 1,8-naphthalimide (donor) to the ring-opened, colored form of rhodamine (acceptor). Moreover, as NR1 is lysosomal with low cytotoxicity, it will be helpful for investigating the pivotal role of H + in a biological context, especially in lysosomes through direct intracellular imaging. [All rights reserved Elsevier].
    Download Collect
  • Anticancer Drug Delivery Systems based on Inorganic Nanocarriers with Fluorescent Tracers

    Fan, Jiangli   Wang, Suzhen   Sun, Wen   Guo, Shigang   Kang, Yao   Du, Jianjun   Peng, Xiaojun  

    Download Collect

    Fluorescent probe compounds, preparation method and use thereof are provided, and said compounds are represented by the general formula I: wherein: each of R1, R2, R3 and R4 is individually selected from the group consisting of H, C1-18 alkyl, phenyl substituted by C1-18 alkyl, naphthyl substituted by C1-18 alkyl, halogen, OR9, N(R9)2, cyano, (CH2CH2O)nH, (CH2)mCOOH, and (CH2)mSO3M; each of R5, R6, R7 and R8 is individually selected from the group consisting of H, C1-18 alkyl, phenyl substituted by C1-18 alkyl, naphthyl substituted by C1-18 alkyl, halogen, hydroxyl, thiol, cyano, nitro, heterocyclic group, halogenated alkyl, alkylamino, amido, OR9, N(R9)2, (CH2CH2O)nH, (CH2)mCOOH, and (CH2)mSO3M; R9 represents H, C1-18 alkyl, phenyl substituted by C1-18 alkyl, naphthyl substituted by C1-18 alkyl, halogen, cyano, (CH2CH2O)nH, (CH2)mCOOH, or (CH2)mSO3M; n and m each individually represent integer of 0-18; M represents H, K, Na, Li, NH4, NH3R10, NH2(R10)2, NH(R10)3, or N(R10)4; and R10 represents H, C1-6 alkyl or CH2CH2OH. The compounds are useful for detecting mercury ion.
    Download Collect

    Fluorescent probe compounds, preparation method and use thereof are disclosed, which well solve the difficult problem that palladium ions quench fluorescence. The compounds have activizing and emissive wavelengths within visible light region, good sensitivity, and good selectivity for palladium ion when pH is near neutral. The fluorescence is obviously enhanced when detecting the palladium ion concentration of 0-10 ppb, and the fluorescent probe can detect the palladium ions of 5nM at lowest. The palladium ion concentration and fluorescence intensity are in good linear relation. The fluorescent probe compounds can be used for detecting Pd pollution and residue in drug, soil, water sample, and catalytic reactor.
    Download Collect

    Disclosed are an anthrapyridone fluorescent dye N-substituted in position 4, the preparation method and use thereof, the compound having a structure as shown in general formula I. In general formula I, n is an integer of 1-10; R is selected from a hydrogen atom, methyl, hydroxyl, amino, dimethylamino, a trimethylammonium halide group and a guanidine hydrochloride group. The anthrapyridone fluorescent dye N-substituted in position 4 in the present invention has a simple synthesis process, good light stability and a relatively long emission wavelength, and has good cell membrane permeability. Thus, another object of the present invention is to provide use of the anthrapyridone fluorescent dye N-substituted in position 4 in the present invention for biological dyeing, such as dyeing in fixed cells, living cells and biological tissues.
    Download Collect

    Disclosed is a class of two-photon fluorescent probes using naphthalene as the matrix;the fluorescent probe has the structure of general formula I, wherein X is selected from Χ1, X2, X3 and X4; the class of two-photon fluorochromes have a lower fluorescent background in non-tumouros cells and tissues, a stronger fluorescent signal in tumouros cells and tissues, and have a very strong specific label for tumouros cells and tissues. Such compounds have a certain level of water solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. Such compounds of the present invention also have lower biotoxicity, phototoxicity and photobleaching at the same time. There is sufficient difference between the spectral range thereof and that of a biological sample.
    Download Collect

    Disclosed are a fuchsin dye, the preparation method and use thereof. A fuchsin dye comprises a compound of general formula (1) or mixtures thereof, wherein a carboxyl group, a sulfonic group, and carbonyl propyl sulfuryl sulfoacid are simultaneously introduced in an anthrapyridone parent. In general formula (1), A can be a cation M4,or substituted or unsubstituted benzyl, or substituted or unsubstituted menaphthyl; M1, M2, and M3 are independent cations or cation groups; the sulfonic group (SO3M2)m can be located at any position in the benzene ring, wherein m is an integer of 0-2. Since the fuchsin dye simultaneously contains a carboxyl (carboxy carbobenzoxy or naphthoate) group, a sulfonic group, and a carbonylpropylsulfuryl group, it can meet many requirements such as shade, brightness, light fastness, water resistance, ozone resistance, solubility, and solution stability.
    Download Collect

    The present invention provides a weather-resistant dye and the use thereof. In addition to a chromophore D, the dye in its molecule has an electron-acceptor group Q, which is linked to the chromophore D via a non-conjugated carbon chain L, forming a dye molecule of D-L-Q, wherein the electron-acceptor group Q has a highest occupied molecular orbital (HOMO) energy level which is lower than that of the chromophore D. The dye has light and ozone resistance, and can be used as colorant in ink, coating, paint, toner for laser printing, mark, paper, fabric, glass, ceramic or polymer.
    Download Collect
  • A Fluorescence Turn-on Sensor for Hg2+with a Simple Receptor Available in Sulphide-Rich Environments

    Fan, Jiangli   Peng, Xiaojun   Wang, Song   Liu, Xiaojian   Li, Honglin   Sun, Shiguo  

    Detection of Hg2+ in complex natural environmental conditions is extremely challenging, and no entirely successful methods currently exist. Here we report an easy-to-prepare fluorescent sensor with 2-aminophenol as Hg2+ receptor, which exhibits selective fluorescence enhancement toward Hg2+ over other metal ions. Especially, the fluorescence enhancement was unaffected by anions and cations existing in environment and organism. Moreover, can detect Hg2+ in sulphide-rich environments without cysteine, S2- or EDTA altering the fluorescence intensity. Consequently, is capable of distinguishing between safe and toxic levels of Hg2+ in more complicated natural water systems with detection limit a parts per thousand currency sign2 ppb.
    Download Collect
  • Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting

    Fan, Jiangli   Guo, Shigang   Wang, Suzhen   Kang, Yao   Yao, Qichao   Wang, Jia   Gao, Xue   Wang, Hongjiang   Du, Jianjun   Peng, Xiaojun  

    Download Collect

    A one-class bi-benzyl pentamethyl cyanine fluorescent dye, and a preparation method and application thereof. The fluorescent dye has the structure of a general formula I. In the formula I, X- is selected from a halogen anion, ClO4 -, PF6 -, CF3 -, BF4 -, R1CO2 -, R2SO3 - or OTs-, wherein R1 and R2 are respectively and independently selected from C1-12 alkyl or aryl. The compound can be used for the fluorescent specificity marker of living cell mitochondria or fixed cell mitochondria.
    Download Collect
1 2 3 4 5 6 7 8 9


If you have any feedback, Please follow the official account to submit feedback.

Turn on your phone and scan

Submit Feedback