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? California and San Diego economy showing signs of improvement? Housing market strengthening? Unemployment declining? But employment conditions still difficult for many? Considerations for LMI workers? Fewer mid‐wage jobs, more low‐wage jobs? Most low‐wage jobs don't pay living wages? Increasing importance of educational attainment

Exquisite in vitro biochemical examinations of protein ubiquitylation and degradation have historically been the dominant methods for unraveling the mechanisms of protein destruction. The study of protein abundance alterations and protein modifications, a cornerstone of protein degradation pathways, naturally lends itself to global and systematic proteomic methods to decipher the emerging complexity of protein degradation pathways. Advances in proteomic technologies have fueled an explosion of systematic and quantitative studies aimed at understanding how the proteome is shaped and regulated by ubiquitin-dependent processes. These types of studies, as well as targeted analyses of cellular pathways, have revealed that alterations in protein degradation function can have a severe impact on human health and disease. The fusion of these two themes was the focus of the January 2012 conference on proteomics of protein degradation and ubiquitin pathways (PPDUP) held in San Diego. To gain insights into both the current state-of-the-art proteomic methods to investigate protein turnover, and how protein degradation function is altered within a range of human disorders a variety of speakers revealed the many connections between altered protein degradation function and human disease. Many of the sessions were framed by a consistent focus aimed at the discovery and development of novel therapeutics targeting protein degradation pathway components to treat various human maladies ranging from cancer to heart disease. Molecular & Cellular Proteomics 11: 10.1074/mcp.O112.020008, 15231528, 2012.

Immigration policy in recent years has led to the deportation of thousands of undocumented parents of US citizen children. In the first six months of FY 2011, almost 47,000 undocumented parents were deported from the country. This article examines how US policy came to allow, if not prescribe, the separation of undocumented parents from their sons and daughters. Drawing on evidence from the San Diego–Tijuana border, it reviews critical moments in the history of deportation and reflects on how that history laid the groundwork for the complex and dysfunctional connections between the immigration and child welfare systems that have led to forced family separation.