Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
home > search

Now showing items 17 - 32 of 28313

  • Mitochondrial H_(2)S_(n)-Mediated Anti-Inflammatory Theranostics

    Won Young Kim[1]   Miae Won[1]   Seyoung Koo[1]   Xingcai Zhang[2,3]   Jong Seung Kim[1]  

    The insistent demand for space-controllable delivery,which reduces the side effects of non-steroidal antiinflammatory drugs(NSAIDs),has led to the development of a new theranostics-based approach for anti-inflammatory therapy.The current anti-inflammatory treatments can be improved by designing a drug delivery system responsive to the inflammatory site biomarker,hydrogen polysulfide(H_(2)S_(n)).Here,we report a noveltheranostic agent 1(TA1),consisting of three parts:H_(2)S_(n)-mediated triggering part,a two-photon fluorophore bearing mitochondria targeting unit(Rhodol-TPP),and anti-inflammatory COX inhibitor(indomethacin).In vitro experiments showed that TA1 selectively reacts with H_(2)S_(n)to concomitantly release both Rhodol-TPP and indomethacin.Confocal-microscopy imaging of inflammation-inducedlive cells suggested that TA1 is localized in the mitochondria where the H_(2)S_(n)is overexpressed.The TA1 reacted with H_(2)S_(n)in the endogenous and exogenous H_(2)S_(n)environments and in lipopolysaccharide treated inflammatory cells.Moreover,TA1 suppressed COX-2 level in the inflammatory-induced cells and prostaglandin E 2(PGE2)level in blood serum from inflammation-induced mouse models.In vivo experiments with inflammation-induced mouse models suggested that TA1 exhibits inflammation-site-elective drug release followed by significant therapeutic e ects,showing its function as a theranostic agent,capable of both anti-inflammatory therapy and precise diagnosis.Theranostic behavior of TA1 is highly applicable in vivo model therapeutics for the inflammatory disease.
    Download Collect
  • Mode-Specific S(N)2 Reaction Dynamics

    Wang, Yan   Song, Hongwei   Szabo, Istvan   Czako, Gabor   Guo, Hua   Yang, Minghui  

    Despite its importance in chemistry, the microscopic dynamics of bimolecular nucleophilic substitution (S(N)2) reactions is still not completely elucidated. In this publication, the dynamics of a prototypical S(N)2 reaction (F- + CH3CL -> CH3F + Cl-) is investigated using a high-dimensional quantum mechanical model on an accurate potential energy surface (PES) and further analyzed by quasi-classical trajectories on the same PES. While the indirect mechanism dominates at low collision energies, the direct mechanism makes a significant contribution. The reactivity is found to depend on the specific reactant vibrational mode excitation. The mode specificity, which is more prevalent in the direct reaction, is rationalized by a transition-state-based model.
    Download Collect
  • Reply to N Karamzad and S Safiri

    Kant, Ashima K; Graubard, Barry I  

    Download Collect
  • The alpha-Effect Exhibited in Gas-Phase S(N)2@N and S(N)2@C Reactions

    Ren, Yi   Wei, Xi-Guang   Ren, Si-Jia   Lau, Kai-Chung   Wong, Ning-Bew   Li, Wai-Kee  

    In order to explore the existence of -effect in gas-phase S(N)2@N reactions, and to compare its similarity and difference with its counterpart in S(N)2@C reactions, we have carried out a theoretical study on the reactivity of six -oxy-Nus (FO-, ClO-, BrO-, HOO-, HSO-, H2NO-) in the S(N)2 reactions toward NR2Cl (R = H, Me) and RCl (R = Me, i-Pr) using the G2(+)(M) theory. An enhanced reactivity induced by the -atom is found in all examined systems. The magnitude of the -effect in the reactions of NR2Cl (R = H, Me) is generally smaller than that in the corresponding S(N)2 reaction, but their variation trend with the identity of -atom is very similar. The origin of the -effect of the S(N)2@N reactions is discussed in terms of activation strain analysis and thermodynamic analysis, indicating that the -effect in the S(N)2@N reactions largely arises from transition state stabilization, and the hyper-reactivity of these -Nus is also accompanied by an enhanced thermodynamic stability of products from the n((N)) sigma*((O-Y)) negative hyperconjugation. Meanwhile, it is found that the reactivity of oxy-Nus in the S(N)2 reactions toward NMe2Cl is lower than toward i-PrCl, which is different from previous experiments, that is, the S(N)2 reactions of NH2Cl is more facile than MeCl. (c) 2013 Wiley Periodicals, Inc.
    Download Collect
  • ?ocuklarda Topuk A?r?s?n?n En S?k Nedeni: Sever Hastal???

    ?ivilibal, Mahmut   Sungur, ?brahim  

    Download Collect
  • Nonrelativistic grey S n -transport radiative-shock solutions

    Ferguson, J.M.   Morel, J.E.   Lowrie, R.B.  

    Download Collect
  • N. HEINSIUS\"S FRAGMENTVM CAESENAS OF OVID\"S METAMORPHOSES REDISCOVERED

    Rivero García   Luis  

    Download Collect
  • Existence of LS+(2(n)4(1))s

    Zheng, Hao   Chang, Yanxun   Zhou, Junling  

    Let X be a (2n+4)-set and G be a partition of X into n groups of size 2 and one group G(0) of size 4. A large-set-plus denoted by LS+(2n41) is a partition of all G-transverse triples of X into 2(n-1) block sets of 3-GDD(2(n)4(1))s with group set G, and two block sets of 3-GDD(2(n))s with group set G\{G0}. In this paper, we study the existence problem of LS+(2n41)s and give a nearly complete solution.
    Download Collect
  • On deformations of AdS (n) x S (n) supercosets

    Hoare, B.   Roiban, R.   Tseytlin, A. A.  

    We study the deformed AdS (5) x S (5) supercoset model of arXiv:1309.5850 which depends on one parameter kappa and has classical quantum group symmetry. We confirm the conjecture that in the "maximal" deformation limit, kappa -> a, this model is T-dual to "flipped" double Wick rotation of the target space AdS (5) x S (5), i.e. dS (5) x H (5) space supported by an imaginary 5-form flux. In the imaginary deformation limit, kappa -> i, the corresponding target space metric is of a pp-wave type and thus the resulting light-cone gauge S-matrix becomes relativistically invariant. Omitting non-unitary contributions of imaginary WZ terms, we find that this tree-level S-matrix is equivalent to that of the generalized sine-Gordon model representing the Pohlmeyer reduction of the undeformed AdS (5) x S (5) superstring model. We also study in some detail similar deformations of the AdS (3) x S (3) and AdS (2) x S (2) supercosets. The bosonic part of the deformed AdS (3) x S (3) model happens to be equivalent to the symmetric case of the sum of the Fateev integrable deformation of the SL(2) and SU(2) principal chiral models, while in the AdS (2) x S (2) case the role of the Fateev model is played by the 2d "sausage" model. The kappa = i limits are again directly related to the Pohlmeyer reductions of the corresponding AdS (n) x S (n) supercosets: (2,2) super sine-Gordon model and its complex sine-Gordon analog. We also discuss possible deformations of AdS (3) x S (3) with more than one parameter.
    Download Collect
  • Pulsating strings from two-dimensional CFT on (T-4)(N)/S(N)

    Cardona, Carlos  

    We propose a state from the two-dimensional conformal field theory on the orbifold (T-4)(N)/S(N) as a dual description for a pulsating string moving in AdS(3). We show that, up to first order in the deforming parameter, the energy in both descriptions has the same dependence on the mode number, but with a non-trivial function of the coupling. (C) 2015 The Author. Published by Elsevier B.V.
    Download Collect
  • doped with W, N, S, W/N, or W/S

    ?elik, Veysel   Mete, Ersen  

    Download Collect
  • Calixarenes and Beyond || Homoheteracalix[n]arenes (X = S, Se, N)

    Neri, Placido   Sessler, Jonathan L.   Wang, Mei-Xiang  

    Download Collect
  • Static pure Lovelock black hole solutions with horizon topology S-(n) x S-(n)

    Dadhich, Naresh   Pons, Josep M.  

    It is well known that vacuum equation of arbitrary Lovelock order for static spacetime ultimately reduces to a single algebraic equation, we show that the same continues to hold true for pure Lovelock gravity of arbitrary order N for topology S-(n) x S-(n). We thus obtain pure Lovelock static black hole solutions with two sphere topology for any order N, and in particular we study in full detail the third and fourth order Lovelock black holes. It is remarkable that thermodynamical stability of black hole discerns between odd and even N, and consequently between negative and positive Lambda and it favors the former while rejecting the latter.
    Download Collect
  • A Prayer to S?n and the Psalms

    Hamme   Joel Travis  

    Download Collect
  • Five-Membered Ring Systems: With N and S Atom

    Wu, Yong-Jin  

    Download Collect
  • Handbuch Soziologie des Alter(n)s || Seniorenwirtschaft

    Schroeter, Klaus R.; Vogel, Claudia; Künemund, Harald  

    Download Collect
1 2 3 4 5 6 7 8 9 10

Contact

If you have any feedback, Please follow the official account to submit feedback.

Turn on your phone and scan

Submit Feedback