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Now showing items 1 - 16 of 39

  • Schwannoma arising from the sublingual gland

    Okada, Hiroyuki   Tanaka, Shigeo   Tajima, Hideto   Akimoto, Yoshiaki   Kaneda, Takashi   Yamamoto, Hirotsugu  

    Sublingual gland tumors, especially mesenchymal tumors, are extremely rare. We describe the first reported case of schwannoma arising from the sublingual gland with details of the histopathologic and immunohistochemical features. A 70-year-old woman developed a painless swelling on the floor of the mouth. The excised material was sublingual gland tissue with an ovoid, grayish-yellow solid tumorous mass at the cut surface. The tumor was composed of proliferated spindle-shaped tumor cells exhibiting palisading patterns. In the center of the tumor, a small salivary gland component was recognized. Immunohistochemically, the tumor cells were strongly positive for S-100 protein but negative for neurofilament protein. The Ki-67 labeling index was 4.58. The clear presence of a remnant sublingual gland lobule in the present tumor provided convincing evidence that it was a schwannoma arising from the sublingual gland and thus the first of its type to be reported. (C) 2012 Elsevier Inc. All rights reserved.
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  • Sialolipoma of the palate: a rare case and review of the literature

    Okada, Hiroyuki   Yokoyama, Megumi   Hara, Masahiro   Akimoto, Yoshiaki   Kaneda, Takashi   Yamamoto, Hirotsugu  

    Sialolipoma is a new variant of salivary gland lipoma, which was first described in 2001. We report a rare case of sialolipoma of the palate, and review another 10 cases affecting the minor salivary gland and 13 affecting the major salivary gland, together with details of the clinical and histopathological findings. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108: 571-576)
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  • Inhibition of G=E2=82=81 cell cycle arrest in human gingival fibroblasts exposed to phenytoin.

    Takeuchi, Reiri   Matsumoto, Hiroko   Akimoto, Yoshiaki   Fujii, Akira  

    Gingival overgrowth is caused in response to the antiepileptic drug phenytoin (PHT). PHT-induced gingival overgrowth is characterized by the proliferation of fibroblasts and increased collagen formation in gingiva. Fibroblast proliferation is regulated through the cell cycle. Thus, in the present study, we examined the effects of PHT on the cell cycle, the expression of cell cycle control proteins and the proliferation in human gingival fibroblasts (hGFs). Cells were stimulated in serum-free DMEM with or without 0.25 mum PHT. Subsequently, the cell cycle phase distribution and the protein expression after 24 h and the cell proliferation after 24, 48 and 72 h were evaluated. PHT significantly inhibited synchronization at the G=E2=82=80/G=E2=82=81 phase of the cell cycle in hGFs through serum starvation. Stimulation with PHT for 48 and 72 h significantly induced a proliferative response in hGFs. PHT decreased the expression of the Cdk-inhibitory proteins p21 and p27 and increased the levels of the S phase-promoting proteins phospho-Thr160-Cdk2 and phospho-Ser807/811-Rb in serum-free DMEM. The inhibition of G=E2=82=81 cell cycle arrest in hGFs may result from an increase in phosphorylated Cdk2 and Rb proteins and decreased levels of p21 and p27 proteins by PHT. The gingival overgrowth may be caused by the failure of the G1 cell cycle arrest in GFs exposed to PHT. =C2=A9 2012 The Authors Fundamental and Clinical Pharmacology =C2=A9 2012 Societe Francaise de Pharmacologie et de Therapeutique.
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  • An orthopantomographic study of hypodontia in permanent teeth of Japanese pediatric patients.

    Goya, Harold Agurto   Tanaka, Shigeo   Maeda, Takahide   Akimoto, Yoshiaki  

    Hypodontia of permanent teeth was evaluated from orthopantomograms of 2072 apparently healthy pediatric patients at The Hospital of Nihon University School of Dentistry at Matsudo. The prevalence of congenitally missing teeth (CMT) was 8.7% in boys and 10.8% in girls, and 9.4% for both sexes combined. Most cases (67.8%) involved either one or two missing teeth. There were in total 574 CMT, and on average 2.8 teeth were missing per child. The most commonly absent tooth was the mandibular second premolar. On the other hand, no first molars were missing in any case. A high frequency of CMT mandibular incisors (18.82%) was observed, and this seems to be a characteristic peculiar to individuals of Asian ethnicity. Oligodontia (6 or more CMT excluding the third molar) ranged from 6 to 14 teeth, with a prevalence of 1.4% in general: 1.8% for girls and 0.9% for boys. Symmetry of CMT was predominant: 214 pairs for bilateral symmetry and 107 pairs for symmetry between two antagonistic quadrants. The distribution of CMT between maxillary and mandibular hypodontia in the right and left quadrants for boys and girls no had significant association (P < 0.05).
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  • Analysis of piston top rings half-stick phenomena using optical technology

    Akimoto, Yoshiaki   Maruya, Takeshi   Sugihara, Hiroyuki   Kobayashi, Hiroyuki  

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  • Incidence of Gingival Overgrowth Induced by Calcium Channel Blocker.

    Akimoto, Yoshiaki   Shibutani, Jun   Nishimura, Hitoshi   Ikeda, Makiko   Ornate, Hiroaki   Takato, Tsuyoshi   Kaneda, Takashi   Yamamoto, Hirotsugu   Hashimoto, Takafumi   Matsumoto, Hiroko   Fujii, Akira  

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  • Effect of Piston Top Rings on Piston Slap Noise

    Akimoto, Yoshiaki   Maruya, Takeshi   Yoshida, Hideki   Kobayashi, Hiroyuki   Sugihara, Hiroyuki  

    A recent increase in detergent additives to gasoline has resulted in an increase in the accumulation of deposits inside the engine's combustion chamber. This type of deposit will be hereinafter referred to as “CCD”; Combustion Chamber Deposit. The authors have also observed an engine noise generated during warm up, which may be attributable to the CCD accumulation.
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  • Effect of oral administration of High Advanced-Collagen Tripeptide (HACP) on bone healing process in rat

    Hata, Saya   Hayakawa, Tohru   Okada, Hiroyuki   Hayashi, Kazuhiko   Akimoto, Yoshiaki   Yamamoto, Hirotsugu  

    The influence of oral administration of High Advanced-Collagen Tripeptide (HACP) developed by Jellice Co., Ltd (Sendai, Japan) for bone repairing process was investigated in rat. Cortical bone defects (1mm diameter) of the tibia were created through the medial cortex and medulla. After I day of operation, HACP/ physiological saline solution (80mg/2ml/Kg) was orally administrated as experimental group. Only physiological saline solution was orally administrated as control group. There were no significant differences in body weight, serum levels of total proteins, calcium concentration and alkaline phosphatase activity between HACP and control groups during administration periods. After 3 weeks of administration, the tibia bone was excised. Micro high-resolution microfocus x-ray computed tomography showed the formation of primary woven bone in HACP group. Histological sections stained with hematoxylin and eosin were observed under light microscope. In control group, blood clot inside the bone defect with a thin connective tissue surrounding the defect was observed. On the contrary, bone defect area was filled with granulation tissue, blood clot and a great number of osteoblasts in the HACP group. The present results suggested that oral administration of HACP may provide a beneficial effect on bone healing process.
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  • Correlation among geometric, densitometric, and mechanical properties in mandible and femur of osteoporotic rats

    Jiang, Gui-Zhen   Matsumoto, Hiroko   Hori, Mami   Gunji, Akihiko   Hakozaki, Kosuke   Akimoto, Yoshiaki   Fujii, Akira  

    We have previously demonstrated bone loss of the mandible and femur in experimental osteoporotic rats and its prevention by medication, using peripheral quantitative computed tomography (pQCT). In the present study, the mechanical properties of the mandible and femur and the correlation to their geometric and densitometric properties were studied in ovariectomized rats with or without etidronate treatment. Fifty-four Wistar strain SPF female rats, 26 weeks old, were randomly assigned to four groups: (1) Basal group (12 rats, 1.0% Ca diet); (2) Sham group (Sham-operated, 12 rats, 0.1% Ca diet); (3) OVX group (ovariectomized, 15 rats, 0.1% Ca diet); (4) Treated group (OVX + etidronate, 15 rats, 0.1% Ca diet). Total bone mineral density (BMD), cortical BMD, cross-sectional cortical bone area, cross-sectional cortical bone thickness, crosssectional moment of inertia (CSMI), and polar strength index (SSI) of the mandible and femur were measured by pQCT. The failure load of mandible and femur was evaluated by three-point bending. The failure load of both bones was significantly lower in the Sham group compared with the Basal group. The OVX group further had a 8% and 7% decrease in the failure load for mandible and femur, respectively, compared to the Sham group. Treatment with etidronate led to an increase in the failure load compared with the OVX group. The failure load was related to the pQCT-assessed variables, especially with cortical bone area and total BMD. Moreover, the geometric and densitometric properties and failure load in the mandible showed a correlation to those in the femur.
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  • Gingival Hyperplasia Induced by Nifedipine.

    AKIMOTO, Yoshiaki   TANAKA, Shigeo   OMATA, Hiroaki   SHIBUTANI, Jun   NAKANO, Yuri   KANEKO, Kenji   KAWANA, Tomonori   TESHIGAWARA, Hiroshi   NAKAO, Sumi   FUJII, Akira   YAMAMOTO, Hirotsugu   MOCHIZUKI, Hiroshi  

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  • A Histopathological and Immunohistochemical Study of Cell Proliferative Activity in Epulis Osteoplastica and Epulis Fibrosa

    Tajima, Hideto   Utsunomiya, Tadahiko   Yamamoto, Hirotsugu   Akimoto, Yoshiaki  

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  • Ampicillin concentrations in human radicular granuloma following a single oral dose of bacampicillin

    Akimoto, Yoshiaki   Kaneko, Kenji   Fujii, Akira   Yamamoto, Hirotsugu  

    Ampicillin concentrations in human serum and radicular granulomas of 42 patients were determined after a single oral dose of bacampicillin (equivalent to 500 mg of ampicillin). Although wide variations were found among both serum and radicular granuloma ampicillin concentrations, measurable concentrations were found in all cases. The mean peak ampicillin concentrations in serum and radicular granulomas occurred at identical times, 1.5 hours, and were 11.19 .mu.g/mL (range, 1.30 to 21.00 .mu.g/mL) and 5.12 .mu.g/g (range, 0.50 to 10.50 .mu.g/g), respectively. The mean radicular granuloma/serum ampicillin concentration ratio at the peak time was 0.42. Ampicillin concentrations in radicular granulomas exceeded most of the minimum inhibitory concentrations for bacteria commonly isolated from odontogenic infections.
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  • Cefaclor Concentration in Pus From Abscess Caused by Odontogenic Infection After a Single Oral Administration

    Akimoto, Yoshiaki   Nishimura, Hitoshi   Omata, Hiroaki   Shibutani, Jun   Kaneko, Kenji   Kawana, Tomonori   et. al.  

    1. Cefaclor concentrations in serum and pus from abscess of odontogenic infection after a single oral administration of 500-mg cefaclor were assayed and pus concentrations were compared with minimum inhibitory concentration (MIC) of oral streptococci isolated from odontogenic infection.
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  • Neurilemmoma in the oral cavity.

    AKIMOTO, Yoshiaki   YAMAMOTO, Hirotsugu   NISHIMURA, Hitoshi   KOMIYA, Masamichi   KANEKO, Kenji  

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  • The effect of IL-1alpha and nifedipine on cell proliferation and DNA synthesis in cultured human gingival fibroblasts.

    Sato, Naoto   Matsumoto, Hiroko   Akimoto, Yoshiaki   Fujii, Akira  

    The effect of nifedipine and interleukin-alpha (IL-1alpha) on the cell proliferation and DNA synthesis was studied in human gingival fibroblasts derived from 5 patients who developed gingival overgrowth (nifedipine responders) and 5 patients who did not develop gingival overgrowth (nifedipine non-responders) in response to nifedipine. Epidermal growth factor was used as a positive control. The fibroblasts derived from nifedipine responders tended to have a numerically greater rate of cell proliferation and DNA synthesis (3H-thymidine incorporation) than those from nifedipine nonresponders in the presence of nifedipine and IL-lalpha. Fibroblasts derived from nifedipine responders showed significantly higher cell proliferation rate in the presence of nifedipine and IL-1alpha, than nifedipine or IL-lalpha alone on both the second and the fourth day of incubation (P < 0.05). A combination of IL-1alpha and epidermal growth factor also showed significantly greater cell proliferation than IL-lalpha alone on the second day (P < 0.05). The DNA synthesis rate with a combination of nifedipine and IL-1alpha was higher than that for nifedipine alone on the second day (P < 0.01), and IL-1alpha alone on the fourth day (P < 0.05) in gingival fibroblasts originating from nifedipine responders. These results suggest that the interaction between nifedipine and gingival inflammation might play an important role in the pathogenesis of nifedipine-induced gingival overgrowth.
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  • Cefadroxil concentrations in human serum, gingiva, and mandibular bone following a single oral administration

    Akimoto, Yoshiaki   Komiya, Masamichi   Kaneko, Kenji   Fujll, Akira  

    Cefadroxil concentrations in human serum, gingiva, and mandibular bone were measured by a paper disk method following a single 500-mg oral dose. The mean peak concentrations in serum, gingiva, and mandibular bone occurred at the identical time, 3 hours, and were 12.92 mug/mL, 6.50 mug/g, and 2.67 mug/g, respectively. Mean cefadroxil concentration ratios of gingiva/serum and mandibular bone/serum at the peak time were 0.54 and 0.21, respectively. Mean concentrations in gingiva and mandibular bone at the peak time exceeded the minimum inhibitory concentrations for 90% of clinically isolated strains of a alpha-hemolytic streptococci.
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