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Kawasaki disease shock syndrome: A report of two cases and literature review

Author:
Qingyou Zhang  Ying Liao  Junbao Du    


Journal:
儿科学(英文)


Issue Date:
2019


Abstract(summary):

Importance:Kawasaki disease shock syndrome (KDSS) is a rare Kawasaki disease (KD) manifestation.The pediatricians are not aware of the full range of clinical characteristics of KDSS.Objective:We aimed to investigate the clinical features,diagnosis and treatment of KDSS in two patients and we included a literature review.Methods:We collected and analyzed the clinical data for two patients with KDSS.Additionally,using 'Kawasaki diseases shock syndrome' as a key phrase,we searched PubMed,Biotechnology Information and Wanfang Data Knowledge Service Platform databases for any similar reports between January 2009 and March 2017.Results:Both of our patients diagnosed with KD developed sustained hypotension during the course of intravenous immunoglobulin treatment,as well as hypoalbuminemia,and increased C-reactive protein and brain natriuretic peptide levels during hypotension.Both patients responded well to fluid resuscitation and inotropic support.No aneurysms formed in either patient during follow-up.We reviewed two related studies in Chinese and 11 studies in English.Interpretation:KD may present with severe shock,and requires proper diagnosis and rapid treatment.The prognosis for most patients with KDSS is excellent.


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