Structural Toxicity:Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes

Journal:

Stem Cell-Derived Models in Toxicology

Issue Date:

2017

Abstract(summary):

Human pluripotent stem cells (hPSC) are investigated as a source of authentic human cardiac cells for drug discovery and toxicological tests. Cell-based assays performed using an automated fluorescence imaging platform and high-content analysis are valuable in characterizing hypertrophic states that may be induced in hPSC-derived cardiomyocytes upon exposure to cardiotoxic compounds. In high-purity populations of hPSC-derived cardiomyocytes loaded with cell tracer probes and other cell markers, detailed hypertrophic profiles can be assessed based on information captured at cellular and subcellular levels.

Page:

271---291