Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
Collection
For ¥0.57 per day, unlimited downloads CREATE MEMBERSHIP Download

toTop

If you have any feedback, Please follow the official account to submit feedback.

Turn on your phone and scan

home > search >

Total glucosides of paeony attenuates animal psoriasis induced inflammatory response through inhibiting STAT1 and STAT3 phosphorylation

Author:
LI Bin-bin  HE Shu-cheng  LIU Rui  HUANG Liang-liang  LIU Ge  WANG Rui-xuan  YANG Zhuo-yue  LIU Xin-yi  LENG Ye  LIU Dan  YE Cheng-yu  LI Yun-man  CHEN Yong-jian  IN Hong  FANG Wei-rong    


Journal:
中国药理学与毒理学杂志


Issue Date:
2019


Abstract(summary):

OBJECTIVE Psoriasis is an immune system meditated disease, especially T cells. It disturbed many people around the world and hard to therapy. Paeonia lactiflora Pall has been used as a medicine in china for thousands of years. Recent studies has found that the main component of Paeonia lactiflora Pall can alleviates the immune response in many diseases. In this study, we researched the effects and possible mechanisms of total glucosides of paeony(TGP) on animal psoriasis in order to study the therapeutic effects and mechanisms of TGP in 5 % propranolol creaminduced psoriasis in guinea pigs and Imiquimod(IMQ) cream-induced psoriasis in mice. METHODS The effect of TGP was evaluated using a psoriasis-like model of guinea pigs and mice. Ear thickness was accessed, and pathology injury was observed by HE staining. The levels of serum IL~(-1)β, IL-6, IL~(-1)2, IL~(-1)7, IL-23, TNF-α, and IFN-γ, skin IL~(-1)7 A, IL-22 and orphan nuclear receptor(RORγt) mR NA expression, proliferating cell nuclear antigen(PCNA), total or phosphorylated signal transducers and activators of transcription(STAT1 and STAT3) were determined by ELISA, real time PCR, immunohistochemical staining, and Western blotting, respectively. RESULTS Compared with model group, TGP treatment decreased the ear thickness, improved pathology of psoriasis, alleviated IMQ-induced keratinocyte proliferation, reduced the inflammatory cytokine, and downregulated IL~(-1)7 A, IL-22, and RORγt mRNA in mice. Further study indicated that TGP inhibited STAT1 and STAT3 phosphorylation in lesion skins of psoriasis-like mice. CONCLUSION TGP alleviates the symptoms of psoriasis-like guinea pigs and mice, and the possible mechanism may relate to inhibit T helper 17(TH17) cell differentiation and keratinocytes proliferation by inhibiting STAT1 and STAT3 phosphorylation.


Page:
112


VIEW PDF

The preview is over

If you wish to continue, please create your membership or download this.

Create Membership

Similar Literature

Submit Feedback

This function is a member function, members do not limit the number of downloads