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Embelin-loaded guar gum microparticles for the management of ulcerative colitis.

Journal:
Journal of microencapsulation


Issue Date:
2018


Abstract(summary):

The aim of the present study is to develop embelin-loaded guar gum microparticles through emulsification technique. The in vitro release of the optimised formulation was found to be 88.5=C2=B13.8% in 24h, has exhibited remarkably sustain and delayed the release of embelin at a specific site. Embelin-loaded microparticles showed average particle size of 12.9=C2=B10.75m. The statistical analysis was carried out by one-way ANOVA followed by comparison test of Bonferroni. P values <0.05 were considered as significant. The in vivo study concluded that pre-treatment of embelin prevents dinitrobenzenesulfonic acid (DNBS)-induced colitis in rats and depicts protective activity against ulcerative colitis due to its antioxidant and anti-inflammatory actions. This approach produces comparatively less side effect to another conventional dosage form.=20


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