Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications

Author:

Yiangou, Loukia  Ross, Alexander D. B.  Goh, Kim Jee  Vallier, Ludovic  

Journal:

CELL STEM CELL

Issue Date:

2018

Abstract(summary):

The liver, lung, pancreas, and digestive tract all originate from the endoderm germ layer, and these vital organs are subject tomany life-threatening diseases affecting millions of patients. However, primary cells from endodermal organs are often difficult to grow in vitro. Human pluripotent stem cells thus hold great promise for generating endoderm cells and their derivatives as tools for the development of new therapeutics against a variety of global healthcare challenges. Here we describe recent advances in methods for generating endodermal cell types from human pluripotent stem cells and their use for disease modeling and cell-based therapy.

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