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Dendrimer-Based Nanodevices as Contrast Agents for MR Imaging Applications

Author:
Sun, Wenjie  Li, Jingchao  Shen, Mingwu  Shi, Xiangyang  


Journal:
ADVANCES IN NANOTHERANOSTICS I: DESIGN AND FABRICATION OF THERANOSIC NANOPARTICLES


Issue Date:
2016


Abstract(summary):

Dendrimers possess unique three-dimensional architectures, highly branched macromolecular characteristics, and abundant terminal functional groups. These properties of dendrimers afford their uses as a versatile nanoplatform to design multifunctional nanodevices for various biomedical applications, especially for magnetic resonance (MR) imaging of different biological systems. The periphery of dendrimers can be linked with targeting ligands and imaging agents, while the unique dendrimer interior and surface functionality render their uses to form dendrimer-entrapped metal nanoparticles (NPs) or dendrimer-assembled magnetic iron oxide NPs. The formed dendrimer-based contrast agents can be used for various MR imaging applications, including T-1-weighted MR, T-2-weighted MR, MR/computed tomography, MR/fluorescence imaging of blood pool, animal organs, and tumors. In particular, this chapter mainly introduces some recent advances of dendrimer-based contrast agents for MR imaging of cancer.


Page:
249---270


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