Base-Mediated Defluorosilylation of C(sp(2))-F and C(sp(3))-F Bonds

Author:

Liu, Xiang-Wei  Zarate, Cayetana  Martin, Ruben  

Journal:

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Issue Date:

2019

Abstract(summary):

The ability to selectively forge C-heteroatom bonds by C-F scission is typically accomplished by metal catalysts, specialized ligands and/or harsh reaction conditions. Described herein is a base-mediated defluorosilylation of unactivated C(sp(2))-F and C(sp(3))-F bonds that obviates the need for metal catalysts. This protocol is characterized by its simplicity, mild reaction conditions, and wide scope, even within the context of late-stage functionalization, constituting a complementary approach to existing C-Si bond-forming protocols.

Page:

2064---2068