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Design of electrospun nanofibrous mats for osteogenic differentiation of mesenchymal stem cells

Author:
Shige Wang  Fei Hu  Jingchao Li  Shuping Zhang  Mingwu Shen  Mingxian Huang  Xiangyang Shi  


Journal:
Nanomedicine: Nanotechnology, Biology and Medicine


Issue Date:
2018


Abstract(summary):

Abstract The clinical translation potential of mesenchymal stem cells (MSCs) in regenerative medicine has been greatly exploited. With the merits of high surface area to volume ratio, facile control of components, well retained topography, and the capacity to mimic the native extracellular matrix (ECM), nanofibers have received a great deal of attention as bone tissue engineering scaffolds. Electrospinning has been considered as an efficient approach for scale-up fabrication of nanofibrous materials. Electrospun nanofibers are capable of stimulating cell–matrix interaction to form a cell niche, directing cellular behavior, and promoting the MSCs adhesion and proliferation. In this review, we give a comprehensive literature survey on the mechanisms of electrospun nanofibers in supporting the MSCs differentiation. Specifically, the influences of biological and physical osteogenic inductive cues on the MSCs osteogenic differentiation are reviewed. Along with the significant advances in the field, current research challenges and future perspectives are also discussed. Graphical Abstract This review gives a comprehensive literature survey on the mechanisms of electrospun nanofibers in supporting the MSCs differentiation. The influences of chemical or physical osteogenic inductive cues on the MSCs osteogenic differentiation are reviewed. Along with the significant advances in the field, current research challenges and future perspectives are also discussed. Image 1 Highlights • The application potentials of various kinds of electrospun nanofibers used for MSCs-based bone tissue engineering were summarized. • Inorganic inductive materials with osteoinductive and osteoconductive properties could alter the mechanical property of electrospun nanofibers, which could be then converted to biochemical signals that are able to active the osteogenic differentiation. • Organic cues could be encapsulated by electrospun nanofibers and their release from the nanofiber matrix could be controlled to a sustained release manner so as to realize a better osteogenic differentiation outcome. • Topological cues included fiber diameter, pores, orientation, patterns and other stimuli such as the mechanical property and surface conductivity could direct the cell growth along the aligned nanofiber orientation or micropattern direction to present different cell shapes, which were conductive for specific differentiation of MSCs.


Page:
2505-2505


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