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Protein adsorption onto polysaccharides: Comparison of chitosan and chitin polymers

Author:
Mohammad Yahyaei  Faramarz Mehrnejad  Hossein Naderi-manesh  Ali Hossein Rezayan  


Journal:
Carbohydrate Polymers


Issue Date:
2018


Abstract(summary):

Highlights • The interaction between FSH and CHS and CHT polymers was studied at atomic-level by MD simulations. • The nonpolar interactions are the most important driving forces for CHS/CHT-FSH interaction. • The protein structure was not changed in the presence of CHS and CHT polymers. • The CHS has more affinity to FSH in compared to CHT. Abstract Chitosan (CHS) and chitin (CHT) biopolymers have found many applications in the field of controlled-release drug delivery systems. Herein, molecular dynamics (MD) simulation and binding free energy calculations were used to investigate the potentials of CHS and CHT polymers for the controlled release of follicle-stimulating hormone (FSH). The results indicated that FSH conformation did not change in the presence of CHS and CHT. In addition, FSH-polymer interactions caused stability of the 3 10 -helix structure of the alpha subunits of FSH (FSHα). Both the biopolymers interacted with the protein mainly through the hydrophobic forces. CHS has more affinity for FSH when compared with CHT. Furthermore, in both systems, the affinity of polymers for FSHα was more than that for beta subunits of FSH (FSHβ). The results suggested that the polysaccharides might improve the controlled-release FSH delivery.


Page:
191-191


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