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Gd-Si Oxide Nanoparticles as Contrast Agents in Magnetic Resonance Imaging

Author:
Alejandro Cabrera-García  Alejandro Vidal-Moya  Ángela Bernabeu  Jesús Pacheco-Torres  Elisa Checa-Chavarria  Eduardo Fernández  Pablo Botella  


Journal:
Nanomaterials


Issue Date:
2016


Abstract(summary):

We describe the synthesis, characterization and application as contrast agents in magnetic resonance imaging of a novel type of magnetic nanoparticle based on Gd-Si oxide, which presents high Gd3+ atom density. For this purpose, we have used a Prussian Blue analogue as the sacrificial template by reacting with soluble silicate, obtaining particles with nanorod morphology and of small size (75 nm). These nanoparticles present good biocompatibility and higher longitudinal and transversal relaxivity values than commercial Gd3+ solutions, which significantly improves the sensitivity of in vivo magnetic resonance images.


Page:
149-152


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