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Cefadroxil concentrations in human serum, gingiva, and mandibular bone following a single oral administration

Author:
Akimoto, Yoshiaki   Komiya, Masamichi   Kaneko, Kenji   Fujll, Akira  


Journal:
Journal of Oral and Maxillofacial Surgery


Issue Date:
1994


Abstract(summary):

Cefadroxil concentrations in human serum, gingiva, and mandibular bone were measured by a paper disk method following a single 500-mg oral dose. The mean peak concentrations in serum, gingiva, and mandibular bone occurred at the identical time, 3 hours, and were 12.92 mug/mL, 6.50 mug/g, and 2.67 mug/g, respectively. Mean cefadroxil concentration ratios of gingiva/serum and mandibular bone/serum at the peak time were 0.54 and 0.21, respectively. Mean concentrations in gingiva and mandibular bone at the peak time exceeded the minimum inhibitory concentrations for 90% of clinically isolated strains of a alpha-hemolytic streptococci.


Page:
397-400


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