Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
Collection
For ¥0.57 per day, unlimited downloads CREATE MEMBERSHIP Download

toTop

If you have any feedback, Please follow the official account to submit feedback.

Turn on your phone and scan

home > search >

The pathologist\"s role in the diagnosis and treatment of osteosarcoma in children

Author:
Alberto G. Ayala   A. Kevin Raymond   Norman Jaffe  


Journal:
Human Pathology


Issue Date:
1984


Abstract(summary):

Tumor specimens from 24 children under 15 yr of age were studied. The children had osteosarcoma and received intra-arterial infusions of cis-platinum before resection or amputation. There were 13 boys and 11 girls, and the median age was 12 yr. Fifteen lesions were located in the femur 4 in the humerus, 3 in the tibia, 1 in the pubis and 1 in the radius. Sixteen patients underwent diagnostic needle biopsies and the remainder, open biopsies. Patients (11) had excellent tumor response, with > 90% tumor destruction in 6 and 65-75% in 5. One patient had 50% tumor destruction, and in 9 patients the response was insignificant. Two patientss had good clinical responses to treatment and refused limb amputation; 1 additional patient died of the disease without amputation or resection. The systematic study of pathology specimens is being undertaken to determine the utility of such a study as a guide to the selection of adjuvant chemotherapy. Patients in whom no responses are obtained should receive alternative treatment, and those in whom responses are optimal should retain the original agent in their adjuvant chemotherapy regimen.


Page:
258-266


VIEW PDF

The preview is over

If you wish to continue, please create your membership or download this.

Create Membership

Similar Literature

Submit Feedback

This function is a member function, members do not limit the number of downloads