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Determination of thickness of walls of hard gelatin capsules by radioisotopic means

Author:
Garnet E. Peck   John E. Christian   Gilbert S. Banker  


Issue Date:
1964


Abstract(summary):

Abstract

A procedure has been developed for the determination of the thickness of the wall sections of hard gelatin capsules. A chlorine-36 source was mounted in the tip of a stainless steel capsule dipping pin and was used to observe the differences in thickness of the wall sections. Twelve series (replications) of 25 determinations each were performed. The measurements taken included the weight, area, calculated weight per unit area, thickness in inches using a micrometer, and beta count rate. The count rates were plotted against the corresponding weight per unit area (mg./cm.2) and thickness (in.). Regression curves were prepared using least squares calculations. A t test was used to compare the individual slopes of the regression curves with the mean slope. The applicability of this method of determining the thickness of wall sections of hard gelatin capsules is discussed.



Page:
607-611


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