Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
Creat membership Creat membership
Sign in

Forgot password?

Confirm
  • Forgot password?
    Sign Up
  • Confirm
    Sign In
Collection

toTop

If you have any feedback, Please follow the official account to submit feedback.

Turn on your phone and scan

home > search >

Inhibiting Amyloid Formation by Peptides with Anti-β-Sheet Conformation: A Novel Therapeutic Approach for Alzheimer's Disease.

Author:
Soto, C.   Kindy, Mark S.   Prelli, Frances   de Beer, Frederick C.   Frangione, Blas  


Journal:
Neurobiology of Aging


Issue Date:
1996


Abstract(summary):

Amyloid formation in Alzheimer's disease (AD) is driven by hydrophobic interactions and dependent on conformational changes in the amyloid-β (Aβ) molecule. The basic unit for fibrillogenesis appears to be the Aβ conformer adopting an antiparallel β-sheet composed of strands involving the regions 10-24 and 29-40/42 of the peptide. Amyloid formation proceeds by intermolecular interactions between the β-strands of several monomers to form an oligomeric β-sheet structure precursor of the fibrillar β-cross conformation. In this study we designed inhibitors of the fibrillogenesis process based on knowledge of the structural determinants for amyloid formation.


Page:
S145


Similar Literature

Submit Feedback

This function is a member function, members do not limit the number of downloads