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PROGNOSTIC FACTORS IN WHO GRADE 2 TRANSITIONAL-CELL BLADDER-CANCER (TCC) - A NOVEL 2-GRADE CLASSIFICATION-SYSTEM FOR TCC BASED ON MITOTIC INDEX

Author:
LIPPONEN, PK  ESKELINEN, MJ  JAUHIAINEN, K  HARJU, E  TERHO, P  HAAPASALO, H  


Journal:
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY


Issue Date:
1992


Abstract(summary):

A retrospective histological analysis has been carried out on 537 cases of transitional-cell bladder carcinoma, followed-up over a period of 9 years. In the first part of the study WHO grade 2 tumours were analysed and a number of independent factors predictive for survival identified. In a multivariate analysis the T category and M/V index (number of mitotic figures/mm2 neoplastic epithelium) were the most important prognostic factors. In a subsequent analysis of the whole series of 537 cases, overall the M/V index was not as important in predicting survival as the stage of the tumour. However, in superficial tumours (Ta-T1) subsequent analysis showed that the M/V index alone could be used to predict survival.


Page:
615---620


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