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A NOVEL TOPICAL TISSUE ADHESIVE COMPOSED OF URETHANE PREPOLYMER MODIFIED WITH CHITOSAN

Author:
Habib, Farzaneh Nayeb  Kordestani, Soheila Salahshoor  Afshar-Taromi, Faramarz  Shariatinia, Zahra  


Journal:
INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION


Issue Date:
2011


Abstract(summary):

A novel tissue adhesive composed of urethane prepolymer and chitosan gel was synthesized. The presence and quantity of NCO groups were determined using FT-IR spectroscopy and titration method, respectively. The adhesion force of the compound was 14.6 N. Chitosan gel in this tissue adhesive was used to increase its biocompatibility. The porous structure, due to the presence of chitosan biopolymer, was illustrated using SEM, and its surface energy was 33.65 mN/m obtained by contact angle measurement. Cytotoxicity of the adhesive was measured using Caco-2, T47D, HT29, and NIH-3T3 cell lines, which exhibited the non-cytotoxic nature of the adhesive.


Page:
609---618


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