Aim of the presented study is to compare the calculated cross sections for the production of (140)Nd/(140)Pr and (114m)In/(114)In via different reactions with incident particle energy up to 50 MeV as a part of systematic studies on particle-induced activations on metal target, theoretical calculation of production yield, calculation of target thickness requirement and suggestion for optimum reaction to produce Neodymium-140 and Indium-114m (140)Nd/(140)Pr and (114m)In/(114)In excitation functions via (nat)Ce((3)He, xn)(140)Nd -> (140)Pr, (141)Pr(p, 2n)(140)Nd -> (140)Pr, (141)Pr(d, 3n)(140)Nd -> (140)Pr, (114)Cd(p, n)(114m)In -> (114)In, (114)Cd(d, 2n)(114m)In -> (114)In and (116)Cd(p, 3n)(114m)In -> (114)In reactions were calculated by ALICE/91, ALICE/ASH (GDH Model & Hybrid Model) and TALYS 1 2 (Equilibrium & Pre-Equilibrium) codes and compared to existing data