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Synthesis of an oxazole-pyrrole-piperazine scaffold as an alpha-helix mimetic

Author:
Moisan, Lionel  Odermatt, Severin  Gombosuren, Naran  Carella, Alexandre  Rebek, Julius, Jr.  


Journal:
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY


Issue Date:
2008


Abstract(summary):

The synthesis of nonpeptidic alpha-helix mimetics based on a tricyclic oxazole-pyrrole-piperazine scaffold is described. The scaffold presents both a hydrophobic surface for recognition and a hydrophilic edge that enhances solubility. The synthesis is highly modular and allows the targeting of a range of protein-protein interactions involving a-helices. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).


Page:
1673---1676


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