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Preparation of [Cu-61]DTPA complex as a possible PET tracer RID H-1769-2011

Author:
Jalilian, AR  Rowshanfarzad, P  Sabet, M  Kamalidehghan, M  


Journal:
NUKLEONIKA


Issue Date:
2006


Abstract(summary):

Copper-61 (T-1/2 = 3.33 h) produced via the Zn-64(p,alpha)Cu-61 nuclear reaction, using a natural zinc target, was separated from the irradiated target material by two ion exchange chromatography steps and was used for the preparation of [Cu-61]-diethylenetriaminepentacetate ([Cu-61]DTPA) using freshly-prepared DTPA cyclic dianhydride. An electroplated natural zinc layer on a gold-coated copper backing was irradiated with 22 MeV protons (22-12 MeV on the target, 180 mu A irradiation, 3.2 h, final activity 220 GBq Of Cu-61(2+), RCY > 95%, radionuclidic purity > 99%, Cu-60 as the only radionuclidic impurity; T-1/2 = 23.7 min). Colorimetric methods showed that traces of chemical impurities in the product were below the accepted limits. The solution of [Cu-61]DTPA was prepared with a radiochemical yield of more than 80% starting with (CuOAc)-Cu-61 ligand at room temperature after 30 min. RTLC showed the radiochemical purity of more than 99%. The specific activity obtained was about 9.1 TBq/mmol. The tracer was shown to be stable in the final product and in the presence of human serum at 37 degrees C up to 3 h.


Page:
111---117


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