Optimization of the production of [Cu-61]Diacetyl-bis(N-4-methylthiosemicarbazone) for PET studies RID H-1769-2011 RID A-3398-2009

Author:

Jalilian, A. R.  Sabet, M.  Rowshanfarzad, P.  Kamali-dehghan, M.  Akhlaghi, M.  Mirzaii, M.  

Journal:

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY

Issue Date:

2006

Abstract(summary):

Copper-61 produced via the Zn-nat(p,x)Cu-61 nuclear reaction was used for the preparation of [Cu-61]diacetyl-bis(N-4-methylthiosemicarbazone) ([Cu-61]ATSM) (4) using a house-made ATSM ligand. After a proton irradiation of an electroplated zinc layer by 22 MeV protons at 180 mA for 3.2 hours, Cu-61 was recovered by two-step chromatography using a cation and an anion exchange column. About 222 GBq (6.00 Ci) of Cu-61(2+) was obtained with a radiochemical separation yield of more than 95% and a radionuclidic purity of better than 99%. Colorimetric methods showed that traces of chemical impurities in the product were below the accepted limits. The [Cu-61]ATSM production was optimized for reaction conditions (buffer concentration and temperature) with a radiochemical yield of higher than 80%, radiochemical purity of better than 98% and a specific activity of about 246 Ci/mmol. The produced [Cu-61]ATSM is a PET radiotracer for hypoxia imaging with an intermediate half life and a satisfactory quality, suitable for future PET studies.

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