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Functional CpG methylation system in a social insect RID A-6078-2008 RID A-5591-2008

Author:
Wang, Ying  Jorda, Mireia  Jones, Peter L.  Maleszka, Ryszard  Ling, Xu  Robertson, Hugh M.  Mizzen, Craig A.  Peinado, Miguel A.  Robinson, Gene E.  


Journal:
SCIENCE


Issue Date:
2006


Abstract(summary):

DNA methylation systems are well characterized in vertebrates, but methylation in Drosophila melanogaster and other invertebrates remains controversial. Using the recently sequenced honey bee genome, we present a bioinformatic, molecular, and biochemical characterization of a functional DNA methylation system in an insect. We report on catalytically active orthologs of the vertebrate DNA methyltransferases Dnmt1 and Dnmt3a and b, two isoforms that contain a methyl-DNA binding domain, genomic 5-methyl-deoxycytosine, and CpG-methylated genes. The honey bee provides an opportunity to study the roles of methylation in social contexts.


Page:
645---647


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