Intracellular pH as a determinant of vascular smooth muscle function RID A-2550-2010

Author:

Wakabayashi, I  Poteser, M  Groschner, K  

Journal:

JOURNAL OF VASCULAR RESEARCH

Issue Date:

2006

Abstract(summary):

Intracellular pH (pH(i)) is a physiological parameter that is intimately linked to contractility, growth and proliferation of vascular smooth muscle (VSM). Regarding contractility, no general unifying concept of pH(i) regulation but a rather complex relation between pH(i) signals and vascular tone has been revealed so far. The modulation of vasotone by pH(i) depends on the type of blood vessel as well as on the pattern of regulatory input signals. In addition, changes in pH(i) have been recognized as an important cellular signal to determine the fate of cells in terms of proliferation or apoptosis. Cellular sensors for pH(i) include a variety of ion transport systems which control intracellular Ca2+ gradients and are likely to serve as a link between pH(i) and cell functions. Here we provide an overview on the potential targets and mechanisms that transduce pH(i) signals in VSM. The role of pH(i)-sensing signaling complexes and localized pH(i) signaling as the basis of diversity of pH(i) regulation of VSM function is discussed. Copyright (c) 2006 S. Karger AG, Basel.

Page:

238---250