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Amphotericin B as a potential probe of the physical state of vesicle membranes RID C-5324-2008

Author:
Zumbuehl, A  Stano, P  Heer, D  Walde, P  Carreira, EM  


Journal:
ORGANIC LETTERS


Issue Date:
2004


Abstract(summary):

The investigations described introduce a new role for a natural product such as amphotericin B as a potential biophysical reporter group to probe the physical state of a membrane. Specifically, we demonstrated that the K+ efflux pattern reveals an interesting sterol dependence. This is suggested to be correlated to the physical state of the membrane showing high efflux in a vesicle membrane of intermediate fluidity.


Page:
3683---3686


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